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Neural Responses to Multielectrode Stimulation of Healthy and Degenerate Retina.
Halupka, Kerry J; Abbott, Carla J; Wong, Yan T; Cloherty, Shaun L; Grayden, David B; Burkitt, Anthony N; Sergeev, Evgeni N; Luu, Chi D; Brandli, Alice; Allen, Penelope J; Meffin, Hamish; Shivdasani, Mohit N.
Afiliação
  • Halupka KJ; NeuroEngineering Laboratory, Department of Biomedical Engineering, The University of Melbourne, Victoria, Australia 2Data61, Commonwealth Scientific and Industrial Research Organisation (CSIRO), New South Wales, Australia 3Bionics Institute, East Melbourne, Victoria, Australia.
  • Abbott CJ; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital; Department of Surgery (Ophthalmology), The University of Melbourne, Victoria, Australia.
  • Wong YT; Department of Physiology, Monash University, Victoria, Australia 6Department of Electrical and Computer Systems Engineering, Monash University, Victoria, Australia.
  • Cloherty SL; Department of Physiology, Monash University, Victoria, Australia 7National Vision Research Institute, Australian College of Optometry, Victoria, Australia.
  • Grayden DB; NeuroEngineering Laboratory, Department of Biomedical Engineering, The University of Melbourne, Victoria, Australia 3Bionics Institute, East Melbourne, Victoria, Australia 8Centre for Neural Engineering, The University of Melbourne, Victoria, Australia.
  • Burkitt AN; NeuroEngineering Laboratory, Department of Biomedical Engineering, The University of Melbourne, Victoria, Australia 3Bionics Institute, East Melbourne, Victoria, Australia.
  • Sergeev EN; NeuroEngineering Laboratory, Department of Biomedical Engineering, The University of Melbourne, Victoria, Australia.
  • Luu CD; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital; Department of Surgery (Ophthalmology), The University of Melbourne, Victoria, Australia.
  • Brandli A; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital; Department of Surgery (Ophthalmology), The University of Melbourne, Victoria, Australia.
  • Allen PJ; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital; Department of Surgery (Ophthalmology), The University of Melbourne, Victoria, Australia.
  • Meffin H; National Vision Research Institute, Australian College of Optometry, Victoria, Australia 9Australian Research Council Centre of Excellence for Integrative Brain Function, Department of Optometry and Vision Sciences, The University of Melbourne, Melbourne, Victoria, Australia.
  • Shivdasani MN; Bionics Institute, East Melbourne, Victoria, Australia 10Department of Medical Bionics, The University of Melbourne, Victoria, Australia.
Invest Ophthalmol Vis Sci ; 58(9): 3770-3784, 2017 07 01.
Article em En | MEDLINE | ID: mdl-28744551
ABSTRACT

Purpose:

Simultaneous stimulation of multiple retinal electrodes in normally sighted animals shows promise in improving the resolution of retinal prostheses. However, the effects of simultaneous stimulation on degenerate retinae remain unknown. Therefore, we investigated the characteristics of cortical responses to multielectrode stimulation of the degenerate retina.

Methods:

Four adult cats were bilaterally implanted with retinal electrode arrays in the suprachoroidal space after unilateral adenosine triphosphate (ATP)-induced retinal photoreceptor degeneration. Functional and structural changes were characterized by using electroretinogram a-wave amplitude and optical coherence tomography. Multiunit activity was recorded from both hemispheres of the visual cortex. Responses to single- and multielectrode stimulation of the ATP-injected and fellow control eyes were characterized and compared.

Results:

The retinae of ATP-injected eyes displayed structural and functional changes consistent with mid- to late-stage photoreceptor degeneration and remodeling. Responses to multielectrode stimulation of the ATP-injected eyes exhibited shortened latencies, lower saturated spike counts, and higher thresholds, compared to stimulation of the fellow control eyes. Electrical receptive field sizes were significantly larger in the ATP-injected eye than in the control eye, and positively correlated with the extent of degeneration.

Conclusions:

Significant differences exist between cortical responses to stimulation of healthy and degenerate retinae. Our results highlight the importance of using a retinal degeneration model when evaluating the efficacy of novel stimulation paradigms.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Degeneração Retiniana / Córtex Visual / Células Fotorreceptoras de Vertebrados / Estimulação Elétrica / Potenciais Evocados Visuais / Próteses Visuais Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Degeneração Retiniana / Córtex Visual / Células Fotorreceptoras de Vertebrados / Estimulação Elétrica / Potenciais Evocados Visuais / Próteses Visuais Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article