High glucose stimulates cell proliferation and Collagen IV production in rat mesangial cells through inhibiting AMPK-K<sub>ATP</sub> signaling.

Zhang, Bei; Shi, Yong-Quan; Zou, Jun-Jie; Chen, Xiang-Fang; Tang, Wei; Ye, Fei; Liu, Zhi-Min

High glucose stimulates cell proliferation and Collagen IV production in rat mesangial cells through inhibiting AMPK-K_ATP signaling.

Zhang, Bei; Shi, Yong-Quan; Zou, Jun-Jie; Chen, Xiang-Fang; Tang, Wei; Ye, Fei; Liu, Zhi-Min.

Afiliação

Zhang B; Department of Endocrinology, Shanghai Changzheng Hospital, No. 415, Fengyang Road, Huangpu District, Shanghai, 200003, People's Republic of China.
Shi YQ; Department of Endocrinology, Shanghai Changzheng Hospital, No. 415, Fengyang Road, Huangpu District, Shanghai, 200003, People's Republic of China. shiyqwz@163.com.
Zou JJ; Department of Endocrinology, Shanghai Changzheng Hospital, No. 415, Fengyang Road, Huangpu District, Shanghai, 200003, People's Republic of China.
Chen XF; Department of Endocrinology, Shanghai Changzheng Hospital, No. 415, Fengyang Road, Huangpu District, Shanghai, 200003, People's Republic of China.
Tang W; Department of Endocrinology, Shanghai Changzheng Hospital, No. 415, Fengyang Road, Huangpu District, Shanghai, 200003, People's Republic of China.
Ye F; Department of Endocrinology, Shanghai Changzheng Hospital, No. 415, Fengyang Road, Huangpu District, Shanghai, 200003, People's Republic of China.
Liu ZM; Department of Endocrinology, Shanghai Changzheng Hospital, No. 415, Fengyang Road, Huangpu District, Shanghai, 200003, People's Republic of China.

Int Urol Nephrol ; 49(11): 2079-2086, 2017 Nov.

Article em En | MEDLINE | ID: mdl-28748494

Assuntos

Proteínas Quinases Ativadas por AMP/metabolismo; Proliferação de Células/efeitos dos fármacos; Colágeno Tipo IV/biossíntese; Glucose/farmacologia; Canais KATP/metabolismo; Células Mesangiais/metabolismo; Receptores de Sulfonilureias/metabolismo; Aminoimidazol Carboxamida/análogos & derivados; Aminoimidazol Carboxamida/farmacologia; Animais; Células Cultivadas; Ácidos Decanoicos/farmacologia; Nefropatias Diabéticas/metabolismo; Diazóxido/farmacologia; Glucose/administração & dosagem; Hidroxiácidos/farmacologia; Hipoglicemiantes/farmacologia; Canais KATP/antagonistas & inibidores; Masculino; Células Mesangiais/efeitos dos fármacos; Canais de Potássio Corretores do Fluxo de Internalização/metabolismo; Ratos; Ratos Sprague-Dawley; Ribonucleotídeos/farmacologia; Transdução de Sinais/efeitos dos fármacos; Receptores de Sulfonilureias/antagonistas & inibidores; Inibidor Tecidual de Metaloproteinase-2/metabolismo

Palavras-chave

AMP-activated protein kinase; Cell proliferation; Collagen IV; High glucose; KATP channel

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Colágeno Tipo IV / Proliferação de Células / Células Mesangiais / Canais KATP / Proteínas Quinases Ativadas por AMP / Receptores de Sulfonilureias / Glucose Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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