General Linker Diversification Approach to Bivalent Ligand Assembly: Generation of an Array of Ligands for the Cation-Independent Mannose 6-Phosphate Receptor.
Org Lett
; 19(16): 4267-4270, 2017 08 18.
Article
em En
| MEDLINE
| ID: mdl-28753028
ABSTRACT
A generalized strategy is presented for the rapid assembly of a set of bivalent ligands with a variety of linking functionalities from a common monomer. Herein, an array of phosphatase-inert mannose-6-phosphonate-presenting ligands for the cation-independent-mannose 6-phosphate receptor (CI-MPR) is constructed. Receptor binding affinity varies with linking functionality-the simple amide and 1,5-triazole(tetrazole) being preferred over the 1,4-triazole. This approach is expected to find application across chemical biology, particularly in glycoscience, wherein multivalency often governs molecular recognition.
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1
Base de dados:
MEDLINE
Assunto principal:
Receptor IGF Tipo 2
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article