Impairment of the carnitine/organic cation transporter 1-ergothioneine axis is mediated by intestinal transporter dysfunction in chronic kidney disease.

Shinozaki, Yasuyuki; Furuichi, Kengo; Toyama, Tadashi; Kitajima, Shinji; Hara, Akinori; Iwata, Yasunori; Sakai, Norihiko; Shimizu, Miho; Kaneko, Shuichi; Isozumi, Noriyoshi; Nagamori, Shushi; Kanai, Yoshikatsu; Sugiura, Tomoko; Kato, Yukio; Wada, Takashi

Shinozaki, Yasuyuki; Furuichi, Kengo; Toyama, Tadashi; Kitajima, Shinji; Hara, Akinori; Iwata, Yasunori; Sakai, Norihiko; Shimizu, Miho; Kaneko, Shuichi; Isozumi, Noriyoshi; Nagamori, Shushi; Kanai, Yoshikatsu; Sugiura, Tomoko; Kato, Yukio; Wada, Takashi.

Afiliação

Shinozaki Y; Division of Nephrology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan.
Furuichi K; Division of Nephrology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan. Electronic address: kfuruichi@m-kanazawa.jp.
Toyama T; Division of Nephrology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan.
Kitajima S; Division of Nephrology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan.
Hara A; Division of Nephrology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan; Department of Environmental and Preventive Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan.
Iwata Y; Division of Nephrology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan.
Sakai N; Division of Nephrology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan.
Shimizu M; Division of Nephrology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan.
Kaneko S; Department of System Biology, Kanazawa University, Kanazawa, Ishikawa, Japan.
Isozumi N; Department of Bio-System Pharmacology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Nagamori S; Department of Bio-System Pharmacology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Kanai Y; Department of Bio-System Pharmacology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Sugiura T; Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Science, Kanazawa University, Kanazawa, Ishikawa, Japan.
Kato Y; Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Science, Kanazawa University, Kanazawa, Ishikawa, Japan.
Wada T; Division of Nephrology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan; Department of Nephrology and Laboratory Medicine, Kanazawa, Ishikawa, Japan.

Kidney Int ; 92(6): 1356-1369, 2017 12.

Article em En | MEDLINE | ID: mdl-28754554

Assuntos

Antioxidantes/metabolismo; Proteínas de Transporte/metabolismo; Ergotioneína/metabolismo; Mucosa Intestinal/metabolismo; Peptídeos e Proteínas de Sinalização Intracelular/metabolismo; Proteínas de Membrana/metabolismo; Insuficiência Renal Crônica/patologia; Animais; Transporte Biológico; Proteínas de Transporte/genética; Linhagem Celular; Membrana Celular/metabolismo; Modelos Animais de Doenças; Progressão da Doença; Regulação para Baixo; Ergotioneína/sangue; Humanos; Intestinos/citologia; Túbulos Renais/citologia; Túbulos Renais/patologia; Masculino; Proteínas de Membrana/genética; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Proteínas de Transporte de Cátions Orgânicos; Estresse Oxidativo; Insuficiência Renal Crônica/sangue; Simportadores; Regulação para Cima

Palavras-chave

chronic kidney disease; fibrosis; oxidative stress

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Transporte / Peptídeos e Proteínas de Sinalização Intracelular / Ergotioneína / Insuficiência Renal Crônica / Mucosa Intestinal / Proteínas de Membrana / Antioxidantes Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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