Telmisartan mitigates hyperglycemia-induced vascular inflammation by increasing GSK3ß-Ser<sup>9</sup> phosphorylation in endothelial cells and mouse aortas.

Song, Kee-Ho; Bae, Sun-Ju; Chang, Jiyeon; Park, Jung-Hyun; Jo, Inho; Cho, Kae Won; Cho, Du-Hyong

Telmisartan mitigates hyperglycemia-induced vascular inflammation by increasing GSK3ß-Ser⁹ phosphorylation in endothelial cells and mouse aortas.

Song, Kee-Ho; Bae, Sun-Ju; Chang, Jiyeon; Park, Jung-Hyun; Jo, Inho; Cho, Kae Won; Cho, Du-Hyong.

Afiliação

Song KH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Konkuk University School of Medicine, 120-1, Neungdong-ro, Hwayang-dong, Gwangjin-gu, Seoul 05030, South Korea.
Bae SJ; Department of Pharmacology, School of Medicine, Eulji University, 77 Gyeryong-ro, 771 Beon-gil, Jung-gu, Daejeon 34824, South Korea.
Chang J; Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, 25 Bongjung-ro, Cheonan, Chungcheongnam do 31151, South Korea.
Park JH; Department of Molecular Medicine, Ewha Womans University Medical School, 1071, Anyangcheon-ro, Yangcheon-gu, Seoul 07985, South Korea.
Jo I; Department of Molecular Medicine, Ewha Womans University Medical School, 1071, Anyangcheon-ro, Yangcheon-gu, Seoul 07985, South Korea.
Cho KW; Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, 25 Bongjung-ro, Cheonan, Chungcheongnam do 31151, South Korea. Electronic address: kwcho@sch.ac.kr.
Cho DH; Department of Pharmacology, School of Medicine, Eulji University, 77 Gyeryong-ro, 771 Beon-gil, Jung-gu, Daejeon 34824, South Korea. Electronic address: biohyong@hanmail.net.

Biochem Biophys Res Commun ; 491(4): 903-911, 2017 09 30.

Article em En | MEDLINE | ID: mdl-28754590

Assuntos

Aorta/efeitos dos fármacos; Benzimidazóis/farmacologia; Benzoatos/farmacologia; Células Endoteliais/efeitos dos fármacos; Glicogênio Sintase Quinase 3 beta/metabolismo; Hiperglicemia/tratamento farmacológico; Inflamação/tratamento farmacológico; Fosfosserina/metabolismo; Vasculite/tratamento farmacológico; Animais; Aorta/metabolismo; Benzimidazóis/administração & dosagem; Benzoatos/administração & dosagem; Bovinos; Células Cultivadas; Relação Dose-Resposta a Droga; Células Endoteliais/metabolismo; Hiperglicemia/metabolismo; Inflamação/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Fosforilação/efeitos dos fármacos; Relação Estrutura-Atividade; Telmisartan; Vasculite/metabolismo

Palavras-chave

Fimasartan (PubChem CID: 9870652); GSK3ß; Hyperglycemia; Losartan (PubChem CID: 3961); Telmisartan; Telmisartan (PubChem CID: 65999); VCAM-1; Vascular inflammation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aorta / Fosfosserina / Vasculite / Benzimidazóis / Benzoatos / Células Endoteliais / Glicogênio Sintase Quinase 3 beta / Hiperglicemia / Inflamação Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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