Hippo signaling pathway in lung development, regeneration, and diseases.
Yi Chuan
; 39(7): 597-606, 2017 Jul 20.
Article
em En
| MEDLINE
| ID: mdl-28757474
ABSTRACT
function between the circulation and the atmospheric environment. Lung diseases, including lung cancer, are among the leading causes of death in the modern society. Research on lung development, regeneration and cancer could provide significant insights for the development of therapeutic approaches on lung diseases. Hippo/YAP/TAZ signaling pathway regulates cell proliferation and differentiation, controls organ size, and plays an important role in response to mechanical forces. YAP/TAZ are expressed in many cell types and serve various regulatory functions in the embryonic and adult lungs. In this review, we mainly focus on the roles of Hippo/YAP/TAZ signaling pathway in embryonic lung development, regeneration and cancer. We postulate that Hippo/YAP/TAZ signaling may play potential roles in regulating the alveolar mechanics and immune responses in the lung.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Regeneração
/
Transdução de Sinais
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Proteínas Serina-Treonina Quinases
/
Pulmão
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Pneumopatias
Tipo de estudo:
Etiology_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article