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An iridium(iii)-based irreversible protein-protein interaction inhibitor of BRD4 as a potent anticancer agent.
Zhong, Hai-Jing; Lu, Lihua; Leung, Ka-Ho; Wong, Catherine C L; Peng, Chao; Yan, Siu-Cheong; Ma, Dik-Lung; Cai, Zongwei; David Wang, Hui-Min; Leung, Chung-Hang.
Afiliação
  • Zhong HJ; State Key Laboratory of Quality Research in Chinese Medicine , Institute of Chinese Medical Sciences , University of Macau , Macao , China . Email: duncanleung@umac.mo.
  • Lu L; Department of Chemistry , Hong Kong Baptist University , Kowloon Tong , Hong Kong , China . Email: edmondma@hkbu.edu.hk.
  • Leung KH; Department of Chemistry , Hong Kong Baptist University , Kowloon Tong , Hong Kong , China . Email: edmondma@hkbu.edu.hk.
  • Wong CCL; National Center for Protein Science Shanghai , State Key Laboratory of Cell Biology , Institute of Biochemistry and Cell Biology , Shanghai Institutes for Biological Sciences , Chinese Academy of Sciences , Shanghai , China.
  • Peng C; National Center for Protein Science Shanghai , State Key Laboratory of Cell Biology , Institute of Biochemistry and Cell Biology , Shanghai Institutes for Biological Sciences , Chinese Academy of Sciences , Shanghai , China.
  • Yan SC; Department of Applied Biology and Chemical Technology , The Hong Kong Polytechnic University , Hung Hom, Kowloon , Hong Kong , China.
  • Ma DL; Department of Chemistry , Hong Kong Baptist University , Kowloon Tong , Hong Kong , China . Email: edmondma@hkbu.edu.hk.
  • Cai Z; Partner State Key Laboratory of Environmental and Biological Analysis , Department of Chemistry , Hong Kong Baptist University , 224 Waterloo Road , Kowloon Tong , Hong Kong SAR , P. R. China . Email: zwcai@hkbu.edu.hk.
  • David Wang HM; Department of Fragrance and Cosmetic Science , Kaohsiung Medical University , Kaohsiung 807 , Taiwan , Republic of China . Email: davidw@kmu.edu.tw.
  • Leung CH; Graduate Institute of Natural Products , Kaohsiung Medical University , Kaohsiung 807 , Taiwan , Republic of China.
Chem Sci ; 6(10): 5400-5408, 2015 Oct 01.
Article em En | MEDLINE | ID: mdl-28757943
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article