Imatinib-induced ophthalmological side-effects in GIST patients are associated with the variations of EGFR, SLC22A1, SLC22A5 and ABCB1.

Qiu, H-B; Zhuang, W; Wu, T; Xin, S; Lin, C-Z; Ruan, H-L; Zhu, X; Huang, M; Li, J-L; Hou, X-Y; Zhou, Z-W; Wang, X-D

Qiu, H-B; Zhuang, W; Wu, T; Xin, S; Lin, C-Z; Ruan, H-L; Zhu, X; Huang, M; Li, J-L; Hou, X-Y; Zhou, Z-W; Wang, X-D.

Afiliação

Qiu HB; Department of Gastric Surgery, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Zhuang W; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Wu T; Department of Gastric Surgery, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Xin S; Department of Gastric Surgery, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Lin CZ; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Ruan HL; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Zhu X; Department of Pharmacy, Huadu District People's Hospital, Guangzhou, China.
Huang M; School of Public Health, Guangzhou Medical University, Guangzhou, China.
Li JL; Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Hou XY; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Zhou ZW; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Wang XD; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.

Pharmacogenomics J ; 18(3): 460-466, 2018 05 22.

Article em En | MEDLINE | ID: mdl-28762371

Assuntos

Oftalmopatias/genética; Predisposição Genética para Doença; Mesilato de Imatinib/efeitos adversos; Leucemia Mielogênica Crônica BCR-ABL Positiva/tratamento farmacológico; Subfamília B de Transportador de Cassetes de Ligação de ATP/genética; Alelos; Receptores ErbB/genética; Oftalmopatias/induzido quimicamente; Oftalmopatias/patologia; Feminino; Frequência do Gene; Genótipo; Humanos; Mesilato de Imatinib/administração & dosagem; Leucemia Mielogênica Crônica BCR-ABL Positiva/complicações; Leucemia Mielogênica Crônica BCR-ABL Positiva/patologia; Masculino; Pessoa de Meia-Idade; Transportador 1 de Cátions Orgânicos/genética; Polimorfismo de Nucleotídeo Único; Membro 5 da Família 22 de Carreadores de Soluto/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mielogênica Crônica BCR-ABL Positiva / Predisposição Genética para Doença / Oftalmopatias / Mesilato de Imatinib Tipo de estudo: Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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