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Porphyrins Conjugated with Peripheral Thiolato Gold(I) Complexes for Enhanced Photodynamic Therapy.
Longevial, Jean-François; El Cheikh, Khaled; Aggad, Dina; Lebrun, Aurélien; van der Lee, Arie; Tielens, Frederik; Clément, Sébastien; Morère, Alain; Garcia, Marcel; Gary-Bobo, Magali; Richeter, Sébastien.
Afiliação
  • Longevial JF; Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-ENSCM-UM, CC 1701, Université de Montpellier, Place Eugène Bataillon, 34095, Montpellier Cedex 05, France.
  • El Cheikh K; Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-ENSCM-UM, Faculté de Pharmacie, 15, Avenue Charles Flahault, 34093, Montpellier Cedex 05, France.
  • Aggad D; Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-ENSCM-UM, Faculté de Pharmacie, 15, Avenue Charles Flahault, 34093, Montpellier Cedex 05, France.
  • Lebrun A; Laboratoire de Mesures Physiques, Université de Montpellier, Place Eugène Bataillon, 34095, Montpellier, France.
  • van der Lee A; Institut Européen des Membranes, UMR 5635 CNRS-ENSCM-UM, Place Eugène Bataillon, 34095, Montpellier, France.
  • Tielens F; Sorbonne Université, UPMC Université Paris 06, UMR 7574, Laboratoire Chimie de la Matière Condensée de Paris, Collège de France, 11 Place Berthelot, 75023, Paris, France.
  • Clément S; Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-ENSCM-UM, CC 1701, Université de Montpellier, Place Eugène Bataillon, 34095, Montpellier Cedex 05, France.
  • Morère A; Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-ENSCM-UM, Faculté de Pharmacie, 15, Avenue Charles Flahault, 34093, Montpellier Cedex 05, France.
  • Garcia M; Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-ENSCM-UM, Faculté de Pharmacie, 15, Avenue Charles Flahault, 34093, Montpellier Cedex 05, France.
  • Gary-Bobo M; Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-ENSCM-UM, Faculté de Pharmacie, 15, Avenue Charles Flahault, 34093, Montpellier Cedex 05, France.
  • Richeter S; Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-ENSCM-UM, CC 1701, Université de Montpellier, Place Eugène Bataillon, 34095, Montpellier Cedex 05, France.
Chemistry ; 23(56): 14017-14026, 2017 Oct 09.
Article em En | MEDLINE | ID: mdl-28763126
Porphyrins fused to imidazolium salts across two neighboring ß-pyrrolic positions were used as N-heterocyclic carbene (NHC) precursors to anchor AuI -Cl complexes at their periphery. Synthesis of several thiolato-AuI complexes was then achieved by substituting chloride for thiolates. Photodynamic properties of these complexes were investigated: the data obtained show that the Au-S bonds could be cleaved upon irradiation. The proposed mechanism to explain the release of thiolate moiety involves the S atom oxidation by singlet oxygen generated in the course of irradiation. In view of photodynamic therapy (PDT) applications, these porphyrins fused to NHC-AuI complexes were tested as photosensitizers to kill MCF-7 breast cancer cells. Results show the important role played by the ancillary ligands (chloride versus thiolates) on the photodynamic effect.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article