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Validation of simplified FABS scale to predict stroke mimics in a Chinese population undergoing intravenous thrombolysis.
Qin, Xiaoming; Zhao, Songyao; Yin, Liujie; Dou, Hailing; Fu, Jing; Wang, Yifan; Li, Mingzhe; Chen, Ruifang; Chen, Jie; Liu, Wei; Yang, Gaiqing; Liu, Xin; Wang, Runqing; Jia, Xinzhou; Bu, Shufang; Ma, Dongpu; Wang, Baoyu; Li, Shize.
Afiliação
  • Qin X; Department of Neurology, Zhengzhou Central Hospital, Zhengzhou University, China; Stroke Center of Zhengzhou Central Hospital, Zhengzhou University, China.
  • Zhao S; Department of Neurology, Zhengzhou Central Hospital, Zhengzhou University, China; Stroke Center of Zhengzhou Central Hospital, Zhengzhou University, China.
  • Yin L; Department of Neurology, Zhengzhou Central Hospital, Zhengzhou University, China; Stroke Center of Zhengzhou Central Hospital, Zhengzhou University, China.
  • Dou H; Department of Neurology, Zhengzhou Central Hospital, Zhengzhou University, China; Stroke Center of Zhengzhou Central Hospital, Zhengzhou University, China.
  • Fu J; Department of Neurology, Zhengzhou Central Hospital, Zhengzhou University, China; Stroke Center of Zhengzhou Central Hospital, Zhengzhou University, China.
  • Wang Y; Department of Neurology, Zhengzhou Central Hospital, Zhengzhou University, China; Stroke Center of Zhengzhou Central Hospital, Zhengzhou University, China.
  • Li M; Department of Neurology, Zhengzhou Central Hospital, Zhengzhou University, China; Stroke Center of Zhengzhou Central Hospital, Zhengzhou University, China.
  • Chen R; Department of Neurology, Zhengzhou Central Hospital, Zhengzhou University, China; Stroke Center of Zhengzhou Central Hospital, Zhengzhou University, China.
  • Chen J; Department of Neurology, Zhengzhou Central Hospital, Zhengzhou University, China; Stroke Center of Zhengzhou Central Hospital, Zhengzhou University, China.
  • Liu W; Department of Neurology, Zhengzhou Central Hospital, Zhengzhou University, China; Stroke Center of Zhengzhou Central Hospital, Zhengzhou University, China.
  • Yang G; Department of Neurology, Zhengzhou Central Hospital, Zhengzhou University, China; Stroke Center of Zhengzhou Central Hospital, Zhengzhou University, China.
  • Liu X; Department of Neurology, Zhengzhou Central Hospital, Zhengzhou University, China; Stroke Center of Zhengzhou Central Hospital, Zhengzhou University, China.
  • Wang R; Department of Neurology, Zhengzhou Central Hospital, Zhengzhou University, China; Stroke Center of Zhengzhou Central Hospital, Zhengzhou University, China.
  • Jia X; Department of Neurology, Zhengzhou Central Hospital, Zhengzhou University, China; Stroke Center of Zhengzhou Central Hospital, Zhengzhou University, China.
  • Bu S; Department of Neurology, Zhengzhou Central Hospital, Zhengzhou University, China; Stroke Center of Zhengzhou Central Hospital, Zhengzhou University, China.
  • Ma D; Stroke Center of Zhengzhou Central Hospital, Zhengzhou University, China; Emergency Department, Zhengzhou Central Hospital, Zhengzhou University, China.
  • Wang B; Stroke Center of Zhengzhou Central Hospital, Zhengzhou University, China; Emergency Department, Zhengzhou Central Hospital, Zhengzhou University, China.
  • Li S; Department of Neurology, Zhengzhou Central Hospital, Zhengzhou University, China; Stroke Center of Zhengzhou Central Hospital, Zhengzhou University, China. Electronic address: 105798738@qq.com.
Clin Neurol Neurosurg ; 161: 1-5, 2017 Oct.
Article em En | MEDLINE | ID: mdl-28763693
ABSTRACT

OBJECTIVES:

A large number of suspected stroke patients undergoing intravenous thrombolysis are stroke mimics (SMs). In this study, we sought to revise the FABS scale for screening and stratifying SMs from acute ischemic stroke (AIS) in a Chinese stroke population receiving fibrinolytic therapy. PATIENTS AND

METHODS:

The simplified FABS (sFABS) scale includes 4 items with 1 point for each item present absence of facial droop, negative history of atrial fibrillation, age <50years, systolic blood pressure <150mm Hg at presentation. We evaluated consecutive suspected stroke patients undergoing intravenous thrombolysis in our stroke center for validation of sFABS scale. Diagnosis of SMs was based on absence of acute ischemic lesions on first and second diffusion weight imaging sequence in addition to an alternate diagnosis at discharge.

RESULTS:

A total of 190 AIS patients and 28 SMs were included in this study from December 2015 to February 2017. The sFABS scale showed excellent discrimination (C statistic 0.928, 95% CI 0.887-0.969, P<0.001). The Hosmer and Lemeshow goodness of fit test showed that the sFABS scale also had a good calibration (Cox and Snell R2=0.294, Nagelkerke R2=0.549). The plot of observed versus predicted risk of SMs showed high correlation (Pearson correlation coefficient 0.983) between observed and predicted risk in our registered stroke population.

CONCLUSION:

The sFABS scale had excellent discrimination and good calibration abilities to predict SMs among a Chinese stroke population receiving tPA therapy. Further imaging evaluation may be necessary before the use of tPA if the sFABS score is higher.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Índice de Gravidade de Doença / Isquemia Encefálica / Acidente Vascular Cerebral / Fibrinolíticos Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male País como assunto: Asia Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Índice de Gravidade de Doença / Isquemia Encefálica / Acidente Vascular Cerebral / Fibrinolíticos Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male País como assunto: Asia Idioma: En Ano de publicação: 2017 Tipo de documento: Article