Synthesis and Biological Evaluation of New Tacrine Analogues under Microwave Irradiation.
Chem Pharm Bull (Tokyo)
; 65(8): 732-738, 2017.
Article
em En
| MEDLINE
| ID: mdl-28768927
ABSTRACT
Efficient routes to various kinds of heterocycles incorporating the p-halophenyl moiety have been synthesized. Different pyrrole derivatives have been synthesized, as well, by Thorpe-Ziegler cyclization. Therefore, we synthesized different analogues of tacrine by Friedländer reaction of o-amino nitriles (pyrazolo, furano and pyrrolo) with different cycloalkanones. The use of microwave irradiation leads to shorter production times and high product conversion. These synthesized compounds were biologically evaluated by Ellman's test on acetylcholinesterase inhibition.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acetilcolinesterase
/
Tacrina
/
Inibidores da Colinesterase
/
Micro-Ondas
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article