Design, synthesis and evaluation of 2,2-dimethyl-1,3-dioxolane derivatives as human rhinovirus 3C protease inhibitors.

Zhang, Qiyan; Cao, Ruiyuan; Liu, An; Lei, Shihai; Li, Yuexiang; Yang, Jingjing; Li, Song; Xiao, Junhai

Zhang, Qiyan; Cao, Ruiyuan; Liu, An; Lei, Shihai; Li, Yuexiang; Yang, Jingjing; Li, Song; Xiao, Junhai.

Afiliação

Zhang Q; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China; Laboratory of Computer-Aided Drug Design and Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. Electronic address: qiyanzhang1113@163.com.
Cao R; Laboratory of Computer-Aided Drug Design and Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. Electronic address: 21cc@163.com.
Liu A; Laboratory of Computer-Aided Drug Design and Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. Electronic address: anran1222@163.com.
Lei S; Laboratory of Computer-Aided Drug Design and Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. Electronic address: leishihai@126.com.
Li Y; Laboratory of Computer-Aided Drug Design and Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. Electronic address: ly19866528@126.com.
Yang J; Laboratory of Computer-Aided Drug Design and Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. Electronic address: yangjingjing@163.com.
Li S; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China; Laboratory of Computer-Aided Drug Design and Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. Electronic address: lis@bmi.ac.cn.
Xiao J; Laboratory of Computer-Aided Drug Design and Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. Electronic address: xiaojunhai@139.com.

Bioorg Med Chem Lett ; 27(17): 4061-4065, 2017 09 01.

Article em En | MEDLINE | ID: mdl-28778471

Assuntos

Dioxolanos/farmacologia; Desenho de Fármacos; Inibidores de Proteases/farmacologia; Rhinovirus/enzimologia; Proteínas Virais/antagonistas & inibidores; Proteases Virais 3C; Cisteína Endopeptidases/metabolismo; Dioxolanos/síntese química; Dioxolanos/química; Relação Dose-Resposta a Droga; Humanos; Estrutura Molecular; Inibidores de Proteases/síntese química; Inibidores de Proteases/química; Relação Estrutura-Atividade; Proteínas Virais/metabolismo

Palavras-chave

2,2-Dimethyl-1, 3-dioxolane derivatives; 3C protease inhibitors; HRV; Virtual screening

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Proteases / Rhinovirus / Proteínas Virais / Desenho de Fármacos / Dioxolanos Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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