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Novel idiopathic DCM-related SCN5A variants localised in DI-S4 predispose electrical disorders by reducing peak sodium current density.
Shen, Cheng; Xu, Lei; Han, Shasha; Dong, Zhen; Zhao, Xiaona; Wang, Shaochun; Qian, Sanli; Li, Bingyu; Ma, Xin; Wang, Peng; Zhu, Hong; Zou, Yunzeng; Fan, Zheng; Ge, Junbo; Sun, Aijun.
Afiliação
  • Shen C; Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Xu L; Department of Cardiology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
  • Han S; Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Dong Z; Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Zhao X; Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Wang S; Department of Cardiology, Huadong Hosptial, Fudan University, Shanghai, China.
  • Qian S; Department of Medical Ultrasound, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
  • Li B; Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Ma X; Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Wang P; Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Zhu H; Institute of Biomedical Science, Fudan University, Shanghai, China.
  • Zou Y; Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Fan Z; Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Ge J; Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Sun A; Institute of Biomedical Science, Fudan University, Shanghai, China.
J Med Genet ; 54(11): 762-770, 2017 11.
Article em En | MEDLINE | ID: mdl-28779003
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sódio / Cardiomiopatia Dilatada / Canal de Sódio Disparado por Voltagem NAV1.5 Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sódio / Cardiomiopatia Dilatada / Canal de Sódio Disparado por Voltagem NAV1.5 Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article