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Drug-related problems in community-dwelling primary care patients screened positive for dementia.
Wucherer, D; Thyrian, J R; Eichler, T; Hertel, J; Kilimann, I; Richter, S; Michalowsky, B; Zwingmann, I; Dreier-Wolfgramm, A; Ritter, C A; Teipel, S; Hoffmann, W.
Afiliação
  • Wucherer D; German Center for Neurodegenerative Diseases (DZNE),Rostock/Greifswald,Greifswald,Germany.
  • Thyrian JR; German Center for Neurodegenerative Diseases (DZNE),Rostock/Greifswald,Greifswald,Germany.
  • Eichler T; German Center for Neurodegenerative Diseases (DZNE),Rostock/Greifswald,Greifswald,Germany.
  • Hertel J; German Center for Neurodegenerative Diseases (DZNE),Rostock/Greifswald,Greifswald,Germany.
  • Kilimann I; German Center for Neurodegenerative Diseases (DZNE),Rostock/Greifswald,Rostock,Germany.
  • Richter S; German Center for Neurodegenerative Diseases (DZNE),Rostock/Greifswald,Greifswald,Germany.
  • Michalowsky B; German Center for Neurodegenerative Diseases (DZNE),Rostock/Greifswald,Greifswald,Germany.
  • Zwingmann I; German Center for Neurodegenerative Diseases (DZNE),Rostock/Greifswald,Greifswald,Germany.
  • Dreier-Wolfgramm A; Institute for Community Medicine,Section Epidemiology of Health Care and Community Health,University Medicine Greifswald,Greifswald,Germany.
  • Ritter CA; Institute of Pharmacy,Section Clinical Pharmacy,University of Greifswald,Greifswald,Germany.
  • Teipel S; Department of Psychiatry and Psychotherapy,University Medicine Greifswald,Greifswald,Germany.
  • Hoffmann W; German Center for Neurodegenerative Diseases (DZNE),Rostock/Greifswald,Greifswald,Germany.
Int Psychogeriatr ; 29(11): 1857-1868, 2017 11.
Article em En | MEDLINE | ID: mdl-28780910
ABSTRACT

BACKGROUND:

Older people have a higher risk of drug-related problems (DRPs). However, little is known about the prevalence of DRPs in community-dwelling people who screened positive for dementia. Our study aimed to determine (1) the prevalence and types of DRPs and (2) the socio-demographic and clinical variables associated with DRPs in people screened positive for dementia in primary care.

METHODS:

The Dementia life- and person-centered help in Mecklenburg-Western Pomerania (DelpHi-MV) study is a general practitioner (GP)-based cluster-randomized controlled intervention study to implement and evaluate an innovative concept of collaborative dementia care management in the primary care setting in Germany. Medication reviews of 446 study participants were conducted by pharmacists based on a comprehensive baseline assessment that included a computer-based home medication assessment. ClinicalTrials.gov Identifier NCT01401582.

RESULTS:

A total of 1,077 DRPs were documented. In 414 study participants (93%), at least one DRP was detected by a pharmacist. The most frequent DRPs were administration and compliance problems (60%), drug interactions (17%), and problems with inappropriate drug choice (15%). The number of DRPs was significantly associated with the total number of drugs taken and with a formal diagnosis of a mental or behavioral disorder.

CONCLUSIONS:

Degree of cognitive impairment (MMSE defined) and formal diagnosis of dementia were not risk factors for an increased number of DRPs. However, the total number of drug taken and the presence of a diagnosis of mental and behavioral disorders were associated with an increased total number of DRPs.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Demência / Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos / Disfunção Cognitiva Tipo de estudo: Clinical_trials / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male País como assunto: Europa Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Demência / Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos / Disfunção Cognitiva Tipo de estudo: Clinical_trials / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male País como assunto: Europa Idioma: En Ano de publicação: 2017 Tipo de documento: Article