Rational Approaches, Design Strategies, Structure Activity Relationship and Mechanistic Insights for Esterase Inhibitors.

Singh, Harbinder; Singh, Jatinder Vir; Kaur, Navdeep; Sanduja, Mohit; Singh, Gurpreet; Bedi, Preet Mohinder Singh; Sharma, Sahil

Singh, Harbinder; Singh, Jatinder Vir; Kaur, Navdeep; Sanduja, Mohit; Singh, Gurpreet; Bedi, Preet Mohinder Singh; Sharma, Sahil.

Afiliação

Singh H; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar-143005, Punjab, India.
Singh JV; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar-143005, Punjab, India.
Kaur N; Department of Chemistry, Guru Nanak Dev University, Amritsar-143005 Punjab, India.
Sanduja M; School of Pharmaceutical Sciences, MVN University, Palwal-121105, Haryana, India.
Singh G; Rajendra Institute of Technology and Sciences, Sirsa-125055, Haryana, India.
Bedi PMS; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar-143005, Punjab, India.
Sharma S; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar-143005, Punjab, India.

Mini Rev Med Chem ; 18(10): 837-894, 2018.

Article em En | MEDLINE | ID: mdl-28782481

Assuntos

Desenho de Fármacos; Inibidores Enzimáticos/farmacologia; Esterases/antagonistas & inibidores; Animais; Inibidores Enzimáticos/química; Esterases/metabolismo; Humanos; Estrutura Molecular; Relação Estrutura-Atividade

Palavras-chave

Alzheimer disease; biological functions; butylcholinesterase; carboxylesterase; hypercholesterolemia; rivastigmine derivatives; tacrine-piperazine hybrid.

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Inibidores Enzimáticos / Esterases Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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