Synthesis and biological evaluation of Aspergillomarasmine A derivatives as novel NDM-1 inhibitor to overcome antibiotics resistance.

Zhang, Jian; Wang, Sanshan; Wei, Qi; Guo, Qianqian; Bai, Yingjie; Yang, Shaoqiang; Song, Fuhang; Zhang, Lixin; Lei, Xiaoguang

Zhang, Jian; Wang, Sanshan; Wei, Qi; Guo, Qianqian; Bai, Yingjie; Yang, Shaoqiang; Song, Fuhang; Zhang, Lixin; Lei, Xiaoguang.

Afiliação

Zhang J; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, and Peking-Tsinghua Center for
Wang S; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, and Peking-Tsinghua Center for
Wei Q; Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Guo Q; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, and Peking-Tsinghua Center for
Bai Y; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, and Peking-Tsinghua Center for
Yang S; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, and Peking-Tsinghua Center for
Song F; Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Zhang L; East China University of Science and Technology, Shanghai 200237, China.
Lei X; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, and Peking-Tsinghua Center for

Bioorg Med Chem ; 25(19): 5133-5141, 2017 10 01.

Article em En | MEDLINE | ID: mdl-28784300

Assuntos

Ácido Aspártico/análogos & derivados; Klebsiella pneumoniae/efeitos dos fármacos; Klebsiella pneumoniae/enzimologia; Inibidores de beta-Lactamases/química; Inibidores de beta-Lactamases/farmacologia; beta-Lactamases/metabolismo; Ácido Aspártico/síntese química; Ácido Aspártico/química; Ácido Aspártico/farmacologia; Humanos; Infecções por Klebsiella/tratamento farmacológico; Infecções por Klebsiella/microbiologia; Resistência beta-Lactâmica/efeitos dos fármacos; Inibidores de beta-Lactamases/síntese química

Palavras-chave

Antibiotic resistance; Antibiotics; Aspergillomarasmine A; Metallo-ß-lactamases; NDM-1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Ácido Aspártico / Inibidores de beta-Lactamases / Klebsiella pneumoniae Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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