Human mitochondrial ribosomes can switch structural tRNAs - but when and why?
RNA Biol
; 14(12): 1668-1671, 2017 12 02.
Article
em En
| MEDLINE
| ID: mdl-28786741
ABSTRACT
High resolution cryoEM of mammalian mitoribosomes revealed the unexpected presence of mitochondrially encoded tRNA as a structural component of mitochondrial large ribosomal subunit (mt-LSU). Our previously published data identified that only mitochondrial (mt-) tRNAPhe and mt-tRNAVal can be incorporated into mammalian mt-LSU and within an organism there is no evidence of tissue specific variation. When mt-tRNAVal is limiting, human mitoribosomes can integrate mt-tRNAPhe instead to generate a translationally competent monosome. Here we discuss the possible reasons for and consequences of the observed plasticity of the structural mt-tRNA integration. We also indicate potential direction for further research that could help our understanding of the mechanistic and evolutionary aspects of this unprecedented system.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
RNA de Transferência
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Ribossomos Mitocondriais
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Mitocôndrias
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article