Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases.
Nat Rev Mol Cell Biol
; 18(10): 595-609, 2017 Oct.
Article
em En
| MEDLINE
| ID: mdl-28792007
ABSTRACT
Ageing is the predominant risk factor for many common diseases. Human premature ageing diseases are powerful model systems to identify and characterize cellular mechanisms that underpin physiological ageing. Their study also leads to a better understanding of the causes, drivers and potential therapeutic strategies of common diseases associated with ageing, including neurological disorders, diabetes, cardiovascular diseases and cancer. Using the rare premature ageing disorder Hutchinson-Gilford progeria syndrome as a paradigm, we discuss here the shared mechanisms between premature ageing and ageing-associated diseases, including defects in genetic, epigenetic and metabolic pathways; mitochondrial and protein homeostasis; cell cycle; and stem cell-regenerative capacity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Senilidade Prematura
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article