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In Vitro activities of Tedizolid and comparator antimicrobial agents against clinical isolates of Staphylococcus aureus collected in 12 countries from 2014 to 2016.
Karlowsky, James A; Hackel, Meredith A; Bouchillon, Samuel K; Alder, Jeff; Sahm, Daniel F.
Afiliação
  • Karlowsky JA; International Health Management Associates, Inc., Schaumburg, IL, USA; Department of Medical Microbiology, College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
  • Hackel MA; International Health Management Associates, Inc., Schaumburg, IL, USA. Electronic address: mhackel@ihmainc.com.
  • Bouchillon SK; International Health Management Associates, Inc., Schaumburg, IL, USA.
  • Alder J; Bayer HealthCare Pharmaceuticals, Montville, NJ, USA.
  • Sahm DF; International Health Management Associates, Inc., Schaumburg, IL, USA.
Diagn Microbiol Infect Dis ; 89(2): 151-157, 2017 Oct.
Article em En | MEDLINE | ID: mdl-28793964
Clinical isolates of Staphylococcus aureus (n=3929) collected by 54 medical center laboratories in 12 countries in 2014-2016 were tested for in vitro susceptibility to tedizolid, linezolid, and 11 comparators using Clinical and Laboratory Standards Institute (CLSI) broth microdilution methodology with minimum inhibitory concentrations (MICs) interpreted by CLSI M100-S26 (2016) criteria. All isolates of S. aureus tested were susceptible to both tedizolid (MIC, ≤0.5µg/mL) and linezolid (MIC, ≤4µg/mL). The concentration of tedizolid that inhibited 90% of isolates (MIC90) was 0.5µg/mL, 4-fold lower than linezolid (MIC90, 2µg/mL). Tedizolid MIC frequency distributions were equivalent for methicillin-susceptible (MSSA; n=2090; MIC90, 0.25µg/mL) and methicillin-resistant (MRSA; n=1839; MIC90, 0.25µg/mL) S. aureus. We conclude that tedizolid possesses more potent in vitro activity than linezolid against recently collected isolates of S. aureus, including isolates of MRSA, and that resistance to currently marketed oxazolidinones (tedizolid and linezolid) remains very uncommon.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxazóis / Organofosfatos / Staphylococcus aureus Resistente à Meticilina / Linezolida / Antibacterianos Tipo de estudo: Guideline Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxazóis / Organofosfatos / Staphylococcus aureus Resistente à Meticilina / Linezolida / Antibacterianos Tipo de estudo: Guideline Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article