Pseudorabies Virus dUTPase UL50 Induces Lysosomal Degradation of Type I Interferon Receptor 1 and Antagonizes the Alpha Interferon Response.

Zhang, Rui; Xu, Aotian; Qin, Chao; Zhang, Qiong; Chen, Shifan; Lang, Yue; Wang, Mengdong; Li, Chuang; Feng, Wenhai; Zhang, Rui; Jiang, Zhengfan; Tang, Jun

Zhang, Rui; Xu, Aotian; Qin, Chao; Zhang, Qiong; Chen, Shifan; Lang, Yue; Wang, Mengdong; Li, Chuang; Feng, Wenhai; Zhang, Rui; Jiang, Zhengfan; Tang, Jun.

Afiliação

Zhang R; State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, China.
Xu A; State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, China.
Qin C; State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, China.
Zhang Q; Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing, China.
Chen S; State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, China.
Lang Y; State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, China.
Wang M; State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, China.
Li C; State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, China.
Feng W; Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing, China.
Zhang R; State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, China.
Jiang Z; State Key Laboratory of Protein and Plant Gene Research, Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing, China.
Tang J; State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, China jtang@cau.edu.cn.

J Virol ; 91(21)2017 11 01.

Article em En | MEDLINE | ID: mdl-28794045

Assuntos

Herpesvirus Suídeo 1/enzimologia; Interferon Tipo I/farmacologia; Lisossomos/metabolismo; Pseudorraiva/metabolismo; Pirofosfatases/metabolismo; Receptor de Interferon alfa e beta/metabolismo; Sequência de Aminoácidos; Animais; Antivirais/farmacologia; Células HeLa; Herpesvirus Suídeo 1/genética; Humanos; Evasão da Resposta Imune; Rim/efeitos dos fármacos; Rim/metabolismo; Rim/virologia; Fosforilação; Proteólise; Pseudorraiva/tratamento farmacológico; Pseudorraiva/virologia; Pirofosfatases/genética; Receptor de Interferon alfa e beta/genética; Homologia de Sequência; Transdução de Sinais; Suínos; Proteínas Virais/genética; Proteínas Virais/metabolismo

Palavras-chave

alphaherpesviruses; dUTPase UL50; interferon signaling; pseudorabies virus; type I interferon receptor 1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pseudorraiva / Pirofosfatases / Interferon Tipo I / Herpesvirus Suídeo 1 / Receptor de Interferon alfa e beta / Lisossomos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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