Direct Interaction of Chivosazole F with Actin Elicits Cell Responses Similar to Latrunculin A but Distinct from Chondramide.

Filipuzzi, Ireos; Thomas, Jason Ray; Pries, Verena; Estoppey, David; Salcius, Michael; Studer, Christian; Schirle, Markus; Hoepfner, Dominic

Filipuzzi, Ireos; Thomas, Jason Ray; Pries, Verena; Estoppey, David; Salcius, Michael; Studer, Christian; Schirle, Markus; Hoepfner, Dominic.

Afiliação

Filipuzzi I; Novartis Institutes for BioMedical Research , Novartis Pharma AG, Forum 1 Novartis Campus, CH-4056 Basel, Switzerland.
Thomas JR; Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Pries V; Novartis Institutes for BioMedical Research , Novartis Pharma AG, Forum 1 Novartis Campus, CH-4056 Basel, Switzerland.
Estoppey D; Novartis Institutes for BioMedical Research , Novartis Pharma AG, Forum 1 Novartis Campus, CH-4056 Basel, Switzerland.
Salcius M; Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Studer C; Novartis Institutes for BioMedical Research , Novartis Pharma AG, Forum 1 Novartis Campus, CH-4056 Basel, Switzerland.
Schirle M; Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Hoepfner D; Novartis Institutes for BioMedical Research , Novartis Pharma AG, Forum 1 Novartis Campus, CH-4056 Basel, Switzerland.

ACS Chem Biol ; 12(9): 2264-2269, 2017 09 15.

Article em En | MEDLINE | ID: mdl-28796488

Assuntos

Actinas/metabolismo; Compostos Bicíclicos Heterocíclicos com Pontes/farmacologia; Depsipeptídeos/farmacologia; Macrolídeos/farmacologia; Tiazolidinas/farmacologia; Citoesqueleto de Actina/efeitos dos fármacos; Citoesqueleto de Actina/genética; Citoesqueleto de Actina/metabolismo; Actinas/genética; Sítios de Ligação; Compostos Bicíclicos Heterocíclicos com Pontes/química; Depsipeptídeos/química; Células HEK293; Humanos; Macrolídeos/química; Mutação; Myxococcales/química; Tiazolidinas/química

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Actinas / Macrolídeos / Compostos Bicíclicos Heterocíclicos com Pontes / Depsipeptídeos / Tiazolidinas Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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