Impact of field number and beam angle on functional image-guided lung cancer radiotherapy planning.
Phys Med Biol
; 62(17): 7114-7130, 2017 Aug 11.
Article
em En
| MEDLINE
| ID: mdl-28800298
ABSTRACT
To investigate the effect of beam angles and field number on functionally-guided intensity modulated radiotherapy (IMRT) normal lung avoidance treatment plans that incorporate hyperpolarised helium-3 magnetic resonance imaging (3He MRI) ventilation data. Eight non-small cell lung cancer patients had pre-treatment 3He MRI that was registered to inspiration breath-hold radiotherapy planning computed tomography. IMRT plans that minimised the volume of total lung receiving ⩾20 Gy (V20) were compared with plans that minimised 3He MRI defined functional lung receiving ⩾20 Gy (fV20). Coplanar IMRT plans using 5-field manually optimised beam angles and 9-field equidistant plans were also evaluated. For each pair of plans, the Wilcoxon signed ranks test was used to compare fV20 and the percentage of planning target volume (PTV) receiving 90% of the prescription dose (PTV90). Incorporation of 3He MRI led to median reductions in fV20 of 1.3% (range 0.2-9.3%; p = 0.04) and 0.2% (range 0 to 4.1%; p = 0.012) for 5- and 9-field arrangements, respectively. There was no clinically significant difference in target coverage. Functionally-guided IMRT plans incorporating hyperpolarised 3He MRI information can reduce the dose received by ventilated lung without comprising PTV coverage. The effect was greater for optimised beam angles rather than uniformly spaced fields.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Planejamento da Radioterapia Assistida por Computador
/
Imageamento por Ressonância Magnética
/
Tomografia Computadorizada por Raios X
/
Carcinoma Pulmonar de Células não Pequenas
/
Radioterapia Guiada por Imagem
/
Neoplasias Pulmonares
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article