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The ATF6α arm of the Unfolded Protein Response mediates replicative senescence in human fibroblasts through a COX2/prostaglandin E2 intracrine pathway.
Cormenier, Johanna; Martin, Nathalie; Deslé, Julie; Salazar-Cardozo, Clara; Pourtier, Albin; Abbadie, Corinne; Pluquet, Olivier.
Afiliação
  • Cormenier J; Univ. Lille, CNRS, Institut Pasteur de Lille, UMR8161, Mechanisms of Tumourigenesis and Targeted Therapies, Lille, France.
  • Martin N; Univ. Lille, CNRS, Institut Pasteur de Lille, UMR8161, Mechanisms of Tumourigenesis and Targeted Therapies, Lille, France.
  • Deslé J; Univ. Lille, CNRS, Institut Pasteur de Lille, UMR8161, Mechanisms of Tumourigenesis and Targeted Therapies, Lille, France.
  • Salazar-Cardozo C; Univ. Lille, CNRS, Institut Pasteur de Lille, UMR8161, Mechanisms of Tumourigenesis and Targeted Therapies, Lille, France.
  • Pourtier A; Univ. Lille, CNRS, Institut Pasteur de Lille, UMR8161, Mechanisms of Tumourigenesis and Targeted Therapies, Lille, France.
  • Abbadie C; Univ. Lille, CNRS, Institut Pasteur de Lille, UMR8161, Mechanisms of Tumourigenesis and Targeted Therapies, Lille, France.
  • Pluquet O; Univ. Lille, CNRS, Institut Pasteur de Lille, UMR8161, Mechanisms of Tumourigenesis and Targeted Therapies, Lille, France. Electronic address: olivier.pluquet@ibl.cnrs.fr.
Mech Ageing Dev ; 170: 82-91, 2018 03.
Article em En | MEDLINE | ID: mdl-28803844

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dinoprostona / Transdução de Sinais / Senescência Celular / Ciclo-Oxigenase 2 / Fator 6 Ativador da Transcrição / Resposta a Proteínas não Dobradas / Fibroblastos Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dinoprostona / Transdução de Sinais / Senescência Celular / Ciclo-Oxigenase 2 / Fator 6 Ativador da Transcrição / Resposta a Proteínas não Dobradas / Fibroblastos Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article