Exosomes in cancer: Use them or target them?
Semin Cell Dev Biol
; 78: 13-21, 2018 06.
Article
em En
| MEDLINE
| ID: mdl-28803894
ABSTRACT
Exosomes are small extracellular vesicles with a significant role in most processes associated with cancer. On one hand, exosomes role in the different hallmarks of cancer has been widely described, highlighting the urge to understand the potential to target communication mediated by exosomes as a novel therapeutic approach in cancer. On the other hand, exosomes stability in circulation and tumor-targeting capacity shows their applicability in the delivery of anti-cancer molecules. This review will discuss the dual applicability of exosomes in cancer focusing on their usage for therapy improvement, or their targeting to block their supportive role in tumor progression and response to therapy. We highlight the current developments and the strategies used to enhance the potential of exosomes to become clinical partners in the treatment of cancer.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Comunicação Celular
/
Exossomos
/
Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article