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Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases.
Roubroeks, Janou A Y; Smith, Rebecca G; van den Hove, Daniel L A; Lunnon, Katie.
Afiliação
  • Roubroeks JAY; University of Exeter Medical School, University of Exeter, Devon, UK.
  • Smith RG; University of Exeter Medical School, University of Exeter, Devon, UK.
  • van den Hove DLA; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.
  • Lunnon K; Laboratory of Translational Neuroscience, Division of Molecular Psychiatry, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany.
J Neurochem ; 143(2): 158-170, 2017 10.
Article em En | MEDLINE | ID: mdl-28805248
ABSTRACT
Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of various neurodegenerative diseases. In this review, we discuss advances that have been made toward understanding the role of epigenetic processes in neurodegenerative disorders, with a particular focus on Alzheimer's disease, where the most extensive studies have been undertaken to date. We provide a brief overview of DNA modifications, followed by a summarization of studies of DNA modifications in Alzheimer's disease and other neurodegenerative diseases.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metilação de DNA / Epigênese Genética / Doença de Alzheimer Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metilação de DNA / Epigênese Genética / Doença de Alzheimer Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article