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The use of 18F-Fluoro-deoxy-glucose positron emission tomography (18F-FDG PET) as a non-invasive pharmacodynamic biomarker to determine the minimally pharmacologically active dose of AZD8835, a novel PI3Kα inhibitor.
Maynard, Juliana; Emmas, Sally-Ann; Ble, Francois-Xavier; Barjat, Herve; Lawrie, Emily; Hancox, Urs; Polanska, Urszula M; Pritchard, Alison; Hudson, Kevin.
Afiliação
  • Maynard J; Personalised Healthcare & Biomarkers, AstraZeneca, Cheshire, United Kingdom.
  • Emmas SA; Personalised Healthcare & Biomarkers, AstraZeneca, Cheshire, United Kingdom.
  • Ble FX; Personalised Healthcare & Biomarkers, AstraZeneca, Cheshire, United Kingdom.
  • Barjat H; Personalised Healthcare & Biomarkers, AstraZeneca, Cheshire, United Kingdom.
  • Lawrie E; Drug Safety and Metabolism iMED, AstraZeneca, Cheshire, United Kingdom.
  • Hancox U; Oncology Imed, Astrazenenca, Cheshire, United Kingdom.
  • Polanska UM; Oncology Imed, Astrazenenca, Cheshire, United Kingdom.
  • Pritchard A; Oncology Imed, Astrazenenca, Cheshire, United Kingdom.
  • Hudson K; Oncology Imed, Astrazenenca, Cheshire, United Kingdom.
PLoS One ; 12(8): e0183048, 2017.
Article em En | MEDLINE | ID: mdl-28806782
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxidiazóis / Piperidinas / Fluordesoxiglucose F18 / Inibidores de Proteínas Quinases / Tomografia por Emissão de Pósitrons / Inibidores de Fosfoinositídeo-3 Quinase Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxidiazóis / Piperidinas / Fluordesoxiglucose F18 / Inibidores de Proteínas Quinases / Tomografia por Emissão de Pósitrons / Inibidores de Fosfoinositídeo-3 Quinase Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article