Palladium(II)-Catalyzed Deacylative Allylic C-H Alkylation.
J Org Chem
; 82(18): 9794-9800, 2017 09 15.
Article
em En
| MEDLINE
| ID: mdl-28809567
ABSTRACT
The first deacylative allylic C-H alkylation has been established by employing the palladium-catalyzed allylic C-H activation and decarboxylative nucleophile generation. A wide scope of nucleophiles are tolerated and densely functionalized alkylation products turn out to be furnished in moderate to good yield. More importantly, this strategy provides an alternative method for the allylic C-H alkylation with less stabilized carbon nucleophiles, and can be further expanded to the synthesis of unconjugated enynes.
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MEDLINE
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article