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Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma.
Robertson, A Gordon; Shih, Juliann; Yau, Christina; Gibb, Ewan A; Oba, Junna; Mungall, Karen L; Hess, Julian M; Uzunangelov, Vladislav; Walter, Vonn; Danilova, Ludmila; Lichtenberg, Tara M; Kucherlapati, Melanie; Kimes, Patrick K; Tang, Ming; Penson, Alexander; Babur, Ozgun; Akbani, Rehan; Bristow, Christopher A; Hoadley, Katherine A; Iype, Lisa; Chang, Matthew T; Cherniack, Andrew D; Benz, Christopher; Mills, Gordon B; Verhaak, Roel G W; Griewank, Klaus G; Felau, Ina; Zenklusen, Jean C; Gershenwald, Jeffrey E; Schoenfield, Lynn; Lazar, Alexander J; Abdel-Rahman, Mohamed H; Roman-Roman, Sergio; Stern, Marc-Henri; Cebulla, Colleen M; Williams, Michelle D; Jager, Martine J; Coupland, Sarah E; Esmaeli, Bita; Kandoth, Cyriac; Woodman, Scott E.
Afiliação
  • Robertson AG; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
  • Shih J; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Yau C; Buck Institute for Research on Aging, Novato, CA 94945, USA.
  • Gibb EA; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
  • Oba J; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Mungall KL; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
  • Hess JM; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
  • Uzunangelov V; Department of Biomolecular Engineering, Center for Biomolecular Sciences and Engineering, University of California, Santa Cruz, CA 95064, USA.
  • Walter V; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Public Health Sciences, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
  • Danilova L; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21287, USA.
  • Lichtenberg TM; The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.
  • Kucherlapati M; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Kimes PK; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Tang M; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Penson A; Human Oncology and Pathogenesis Program, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.
  • Babur O; Molecular and Medical Genetics, Computational Biology, Oregon Health and Science University, Portland, OR 97239, USA.
  • Akbani R; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Bristow CA; Institute for Applied Cancer Science, Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Hoadley KA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Iype L; Institute for Systems Biology, Seattle, WA 98109, USA.
  • Chang MT; Human Oncology and Pathogenesis Program, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA; Departments of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94122, USA.
  • Cherniack AD; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Benz C; Buck Institute for Research on Aging, Novato, CA 94945, USA.
  • Mills GB; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Verhaak RGW; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Griewank KG; Department of Dermatology, University Hospital Essen, 45157 Essen, Germany.
  • Felau I; Center for Cancer Genomics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Zenklusen JC; Center for Cancer Genomics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Gershenwald JE; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Schoenfield L; Department of Pathology, The Ohio State University, Wexner Medical Center, Columbus, OH 43210, USA.
  • Lazar AJ; Department of Pathology, Dermatology and Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Abdel-Rahman MH; Departments of Ophthalmology and Internal Medicine, Division of Human Genetics, The Ohio State University, Columbus, OH 43210, USA.
  • Roman-Roman S; Department of Translational Research, Institut Curie, PSL Research University, Paris 75248, France.
  • Stern MH; Department of Translational Research, Institut Curie, PSL Research University, Paris 75248, France.
  • Cebulla CM; Havener Eye Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43212, USA.
  • Williams MD; Department of Pathology, Dermatology and Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Jager MJ; Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands.
  • Coupland SE; Department of Molecular & Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool L7 8TX, UK; Department of Cellular Pathology, Royal Liverpool University Hospital, Liverpool, L69 3GA, UK.
  • Esmaeli B; Orbital Oncology & Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: besmaeli@mdanderson.org.
  • Kandoth C; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA. Electronic address: kandothc@mskcc.org.
  • Woodman SE; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: swoodman@mdanderson.org.
Cancer Cell ; 32(2): 204-220.e15, 2017 08 14.
Article em En | MEDLINE | ID: mdl-28810145
ABSTRACT
Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four molecularly distinct, clinically relevant subtypes two associated with poor-prognosis monosomy 3 (M3) and two with better-prognosis disomy 3 (D3). We show that BAP1 loss follows M3 occurrence and correlates with a global DNA methylation state that is distinct from D3-UM. Poor-prognosis M3-UM divide into subsets with divergent genomic aberrations, transcriptional features, and clinical outcomes. We report change-of-function SRSF2 mutations. Within D3-UM, EIF1AX- and SRSF2/SF3B1-mutant tumors have distinct somatic copy number alterations and DNA methylation profiles, providing insight into the biology of these low- versus intermediate-risk clinical mutation subtypes.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Uveais / Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / Metilação de DNA / Melanoma / Mutação Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Uveais / Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / Metilação de DNA / Melanoma / Mutação Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article