Chronic morphine reduces the readily releasable pool of GABA, a presynaptic mechanism of opioid tolerance.

Wilson-Poe, Adrianne R; Jeong, Hyo-Jin; Vaughan, Christopher W

Wilson-Poe, Adrianne R; Jeong, Hyo-Jin; Vaughan, Christopher W.

Afiliação

Wilson-Poe AR; Pain Management Research Institute, Kolling Institute of Medical Research, Northern Clinical School, The University of Sydney and Royal North Shore Hospital, St Leonards, New South Wales, 2065, Australia.
Jeong HJ; Pain Management Research Institute, Kolling Institute of Medical Research, Northern Clinical School, The University of Sydney and Royal North Shore Hospital, St Leonards, New South Wales, 2065, Australia.
Vaughan CW; Pain Management Research Institute, Kolling Institute of Medical Research, Northern Clinical School, The University of Sydney and Royal North Shore Hospital, St Leonards, New South Wales, 2065, Australia.

J Physiol ; 595(20): 6541-6555, 2017 10 15.

Article em En | MEDLINE | ID: mdl-28815604

Assuntos

Analgésicos Opioides/farmacologia; Tolerância a Medicamentos/fisiologia; Morfina/farmacologia; Substância Cinzenta Periaquedutal/efeitos dos fármacos; Ácido gama-Aminobutírico/metabolismo; Animais; Masculino; Neurônios/efeitos dos fármacos; Neurônios/fisiologia; Substância Cinzenta Periaquedutal/fisiologia; Ratos Sprague-Dawley; Transmissão Sináptica/efeitos dos fármacos

Palavras-chave

opioid; synaptic transmission; tolerance

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Substância Cinzenta Periaquedutal / Tolerância a Medicamentos / Ácido gama-Aminobutírico / Analgésicos Opioides / Morfina Tipo de estudo: Guideline Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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