Complete amino acid sequence of rat liver alcohol dehydrogenase deduced from the cDNA sequence.
Gene
; 48(2-3): 287-91, 1986.
Article
em En
| MEDLINE
| ID: mdl-2881847
ABSTRACT
Alcohol dehydrogenase (ADH) catalyzes the rate-determining reaction in the metabolism of ethanol. We report here the complete nucleotide sequence of a cDNA encoding rat liver ADH, and the deduced amino acid (aa) sequence of the protein. The rat enzyme contains a cluster of aa substitutions and an aa insertion in the region between aa residues 111 and 118, which is near the intron-exon junction reported for the human ADH gene. It also contains an additional cysteine in the highly variable region from aa residues 108-125 which may account for the unusual lability of rat ADH compared with ADH from other species.
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Base de dados:
MEDLINE
Assunto principal:
Ratos
/
Álcool Desidrogenase
/
DNA
/
Fígado
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1986
Tipo de documento:
Article