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Presence of quintuple dhfr N51, C59, S108 - dhps A437, K540 mutations in Plasmodium falciparum isolates from pregnant women and the general population in Nanoro, Burkina Faso.
Ruizendaal, Esmée; Tahita, Marc C; Traoré-Coulibaly, Maminata; Tinto, Halidou; Schallig, Henk D F H; Mens, Petra F.
Afiliação
  • Ruizendaal E; Medical Microbiology, Parasitology, Academic Medical Centre, Amsterdam, The Netherlands. Electronic address: esmee.ruizendaal@gmail.com.
  • Tahita MC; Institut de Recherche en Sciences de la Santé- Unité de Recherche Clinique de Nanoro, (IRSS-URCN), Nanoro, Burkina Faso. Electronic address: marctahita@yahoo.fr.
  • Traoré-Coulibaly M; Institut de Recherche en Sciences de la Santé- Unité de Recherche Clinique de Nanoro, (IRSS-URCN), Nanoro, Burkina Faso. Electronic address: traore_maminata@yahoo.fr.
  • Tinto H; Institut de Recherche en Sciences de la Santé- Unité de Recherche Clinique de Nanoro, (IRSS-URCN), Nanoro, Burkina Faso. Electronic address: tintohalidou@yahoo.fr.
  • Schallig HDFH; Medical Microbiology, Parasitology, Academic Medical Centre, Amsterdam, The Netherlands. Electronic address: h.d.schallig@amc.uva.nl.
  • Mens PF; Medical Microbiology, Parasitology, Academic Medical Centre, Amsterdam, The Netherlands. Electronic address: p.f.mens@amc.uva.nl.
Mol Biochem Parasitol ; 217: 13-15, 2017 10.
Article em En | MEDLINE | ID: mdl-28818675
ABSTRACT
Sulphadoxine-pyrimethamine (SP) is only used for intermittent preventive treatment during pregnancy (IPTp) in most Sub-Saharan African countries. However, there are concerns about the efficacy of IPTp-SP because of increasing resistance. Combinations of point mutations in the dhps and dhfr genes of Plasmodium falciparum are associated with SP resistance, in particular the quintuple dhfr (N51, C59, S108) - dhps (codons A437, K540) mutant. In Nanoro, Burkina Faso, filter paper samples from pregnant women at first antenatal care visit and at delivery plus samples from the general population (GP) were studied for dhfr and dhps mutations by sequencing. Quintuple mutants were present in 2 delivery and 4 GP samples. This is the first time the quintuple mutation is found in Burkina Faso and although the prevalence is still very low, emergence of the quintuple mutation could highly diminish the efficacy of IPTp-SP. Close surveillance of SP resistance mutations is therefore warranted.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Tetra-Hidrofolato Desidrogenase / Proteínas de Protozoários / Malária Falciparum / Complicações Parasitárias na Gravidez Tipo de estudo: Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged / Pregnancy País como assunto: Africa Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Tetra-Hidrofolato Desidrogenase / Proteínas de Protozoários / Malária Falciparum / Complicações Parasitárias na Gravidez Tipo de estudo: Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged / Pregnancy País como assunto: Africa Idioma: En Ano de publicação: 2017 Tipo de documento: Article