Activation of Nuclear Factor-&#954;B by Tumor Necrosis Factor in Intestinal Epithelial Cells and Mouse Intestinal Epithelia Reduces Expression of the Chloride Transporter SLC26A3.

Kumar, Anoop; Chatterjee, Ishita; Gujral, Tarunmeet; Alakkam, Anas; Coffing, Hayley; Anbazhagan, Arivarasu N; Borthakur, Alip; Saksena, Seema; Gill, Ravinder K; Alrefai, Waddah A; Dudeja, Pradeep K

Activation of Nuclear Factor-κB by Tumor Necrosis Factor in Intestinal Epithelial Cells and Mouse Intestinal Epithelia Reduces Expression of the Chloride Transporter SLC26A3.

Kumar, Anoop; Chatterjee, Ishita; Gujral, Tarunmeet; Alakkam, Anas; Coffing, Hayley; Anbazhagan, Arivarasu N; Borthakur, Alip; Saksena, Seema; Gill, Ravinder K; Alrefai, Waddah A; Dudeja, Pradeep K.

Afiliação

Kumar A; Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois.
Chatterjee I; Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois.
Gujral T; Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois.
Alakkam A; Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois.
Coffing H; Department of Microbiology and Immunology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois.
Anbazhagan AN; Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois.
Borthakur A; Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois.
Saksena S; Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois; Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois.
Gill RK; Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois.
Alrefai WA; Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois; Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois.
Dudeja PK; Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois; Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois. Electronic address: pkdudeja@uic.edu.

Gastroenterology ; 153(5): 1338-1350.e3, 2017 11.

Article em En | MEDLINE | ID: mdl-28823863

Assuntos

Antiporters/metabolismo; Antiportadores de Cloreto-Bicarbonato/metabolismo; Diarreia/etiologia; Células Epiteliais/efeitos dos fármacos; Doenças Inflamatórias Intestinais/complicações; Mucosa Intestinal/efeitos dos fármacos; NF-kappa B/metabolismo; Fator de Necrose Tumoral alfa/farmacologia; Animais; Antiporters/genética; Células CACO-2; Antiportadores de Cloreto-Bicarbonato/genética; Diarreia/genética; Diarreia/metabolismo; Relação Dose-Resposta a Droga; Regulação para Baixo; Células Epiteliais/metabolismo; Células Epiteliais/patologia; Células HT29; Humanos; Doenças Inflamatórias Intestinais/genética; Doenças Inflamatórias Intestinais/metabolismo; Absorção Intestinal/efeitos dos fármacos; Mucosa Intestinal/metabolismo; Mucosa Intestinal/patologia; Camundongos; Camundongos Endogâmicos C57BL; NF-kappa B/genética; Regiões Promotoras Genéticas; Interferência de RNA; Transportadores de Sulfato; Fatores de Tempo; Transfecção

Palavras-chave

Intestinal Inflammation; Ion Transporter; Mouse Model; NaCl Absorption

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / NF-kappa B / Fator de Necrose Tumoral alfa / Antiporters / Antiportadores de Cloreto-Bicarbonato / Diarreia / Células Epiteliais / Mucosa Intestinal Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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