B-cell receptor sequencing of anti-citrullinated protein antibody (ACPA) IgG-expressing B cells indicates a selective advantage for the introduction of <i>N</i>-glycosylation sites during somatic hypermutation.

Vergroesen, Rochelle D; Slot, Linda M; Hafkenscheid, Lise; Koning, Marvyn T; van der Voort, Ellen I H; Grooff, Christine A; Zervakis, George; Veelken, Hendrik; Huizinga, Tom W J; Rispens, Theo; Scherer, Hans U; Toes, René E M

B-cell receptor sequencing of anti-citrullinated protein antibody (ACPA) IgG-expressing B cells indicates a selective advantage for the introduction of N-glycosylation sites during somatic hypermutation.

Vergroesen, Rochelle D; Slot, Linda M; Hafkenscheid, Lise; Koning, Marvyn T; van der Voort, Ellen I H; Grooff, Christine A; Zervakis, George; Veelken, Hendrik; Huizinga, Tom W J; Rispens, Theo; Scherer, Hans U; Toes, René E M.

Afiliação

Vergroesen RD; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Slot LM; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Hafkenscheid L; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Koning MT; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
van der Voort EIH; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Grooff CA; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Zervakis G; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
Veelken H; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
Huizinga TWJ; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Rispens T; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, The Netherlands.
Scherer HU; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Toes REM; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

Ann Rheum Dis ; 77(6): 956-958, 2018 06.

Article em En | MEDLINE | ID: mdl-28835463

Assuntos

Artrite Reumatoide/genética; Autoanticorpos/genética; Peptídeos Cíclicos/imunologia; Receptores de Antígenos de Linfócitos B/genética; Hipermutação Somática de Imunoglobulina; Autoantígenos/imunologia; Linfócitos B/imunologia; Glicosilação; Humanos; Imunoglobulina G/genética

Palavras-chave

B cells; ant-ccp; autoantibodies; autoimmunity; rheumatoid arthritis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos / Artrite Reumatoide / Autoanticorpos / Receptores de Antígenos de Linfócitos B / Hipermutação Somática de Imunoglobulina Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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