Circadian Clocks and Metabolism: Implications for Microbiome and Aging.
Trends Genet
; 33(10): 760-769, 2017 10.
Article
em En
| MEDLINE
| ID: mdl-28844699
ABSTRACT
The circadian clock directs many aspects of metabolism, to separate in time opposing metabolic pathways and optimize metabolic efficiency. The master circadian clock of the suprachiasmatic nucleus synchronizes to light, while environmental cues such as temperature and feeding, out of phase with the light schedule, may synchronize peripheral clocks. This misalignment of central and peripheral clocks may be involved in the development of disease and the acceleration of aging, possibly in a gender-specific manner. Here we discuss the interplay between the circadian clock and metabolism, the importance of the microbiome, and how they relate to aging.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
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Relógios Circadianos
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Microbiota
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article