Association of HTRA1 rs11200638 with age-related macular degeneration (AMD) in Brazilian patients.
Ophthalmic Genet
; 39(1): 46-50, 2018.
Article
em En
| MEDLINE
| ID: mdl-28846052
ABSTRACT
Age-related macular degeneration is a multifactorial disease that can lead to vision impairment in older individuals. Although the etiology of age-related macular degeneration remains unknown, risk factors include age, ethnicity, smoking, hypertension, obesity, and genetic factors. Two main loci have been identified through genome-wide association studies, on chromosomes 1 and 10. Among the variants located at the 10q26 region, rs11200638, located at the HTRA1 gene promoter, has been associated with age-related macular degeneration in several populations and is considered the main polymorphism. We conducted a replication case-control study to analyze the frequency and participation of rs11200638 in the etiology of age-related macular degeneration in a sample of patients and controls from the State of São Paulo, Brazil, through polymerase chain reaction and enzymatic digestion. The frequency of the A allele was 57.60% in patients with age-related macular degeneration and 36.45% in controls (p value < 1e-07), representing a 2.369-fold higher risk factor for the disease. Both the AA and AG genotypes were observed more frequently in the age-related macular degeneration group compared to the control group (p = 1.21e-07 and 0.0357, respectively). No statistically significant results were observed after stratification in dry versus wet types or advanced versus non-advanced forms. To our knowledge, this is the first time the association between rs11200638 and overall age-related macular degeneration has been reported in South America.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo de Nucleotídeo Único
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Atrofia Geográfica
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Degeneração Macular Exsudativa
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Serina Peptidase 1 de Requerimento de Alta Temperatura A
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
País como assunto:
America do sul
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Brasil
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article