Carbon-ion radiotherapy for non-small cell lung cancer with interstitial lung disease: a retrospective analysis.
Radiat Oncol
; 12(1): 144, 2017 Sep 02.
Article
em En
| MEDLINE
| ID: mdl-28865463
ABSTRACT
BACKGROUND:
Lung cancer is frequently complicated by interstitial lung disease (ILD). Treatment protocols for lung cancer patients with ILD have not been established; surgery, chemotherapy, and radiotherapy can all cause acute exacerbation of ILD. This study evaluated the toxicity and efficacy of carbon ion radiotherapy (CIRT) in patients with non-small cell lung cancer (NSCLC) and ILD.METHODS:
Between June 2004 and November 2014, 29 patients diagnosed with NSCLC and ILD were treated with CIRT. No patient was eligible for curative surgery or conventional radiotherapy secondary to ILD. Owing to prior symptomology, radiation pneumonitis (RP) and symptom progression pre- and post-treatment were evaluated. The relationships between RP and clinical factors were investigated.RESULTS:
Twenty-eight men and one woman, aged 62 to 90 years old, were followed for 2.7-77.1 months (median 22.8 months). Single-grade symptomatic progression (grade 2-3) was observed in 4 patients, while 1 patient experiencedtwo-grade progression. Two patients experienced radiation-induced acute exacerbation. Local control at 3 years was 63.3% (72.2% for stage I disease); survival at 3 years was 46.3% (57.2% for stage I disease). Eighteen patients had died by the time of this writing, 10 of lung cancer progression. Radiation pneumonitis post-treatment progression correlated with dosimetric factors of the lungs (V5, V10) and a low pre-treatment serum surfactant protein-D.CONCLUSIONS:
We found that CIRT may be useful as a low-risk, curative option for NSCLC patients with ILD, a population that is typically ineligible for conventional therapy. The DVH analysis showed that minimizing the low-dose region is important for reducing the risk of severe RP. TRIAL REGISTRATION NIRS-9404 . Registered 1 March 1994.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doenças Pulmonares Intersticiais
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Carcinoma Pulmonar de Células não Pequenas
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Radioterapia com Íons Pesados
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Neoplasias Pulmonares
Tipo de estudo:
Guideline
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Observational_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article