The quantitative link of lung clearance index to bronchial segments affected by bronchiectasis.
Thorax
; 73(1): 82-84, 2018 01.
Article
em En
| MEDLINE
| ID: mdl-28866642
ABSTRACT
In adult patients with cystic fibrosis (CF), the lung clearance index (LCI) derived from the multiple breath washout relates to both acinar and conductive ventilation heterogeneity. The latter component predicts an association between LCI and the number of bronchial segments affected by bronchiectasis. Here, we experimentally demonstrated this association in patients with CF, and also examined an ancillary group of patients with non-CF bronchiectasis. We conclude that lung disease severity in terms of number of bronchial segments results in an associated LCI increase, likely constituting a portion of LCI that cannot be reversed by treatment in patients with CF lung disease.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bronquiectasia
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Fibrose Cística
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article