Heterogeneity among Lgr5-positive colon stem cells.
Mol Cell Oncol
; 4(4): e1335271, 2017.
Article
em En
| MEDLINE
| ID: mdl-28868346
Leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) is considered a representative marker of intestinal stem cells from both non-tumor and tumor tissues. However, it remains unclear whether all or only a fraction of Lgr5-positive cells behave as stem cells. Recently, we reported that Lgr5-positive cells from non-tumor and tumor tissues can be classified into overlapping yet distinct groups and that the tumor-specific groups are associated with tumorigenic capability, suggesting that these cells could represent targets for therapeutic intervention.
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MEDLINE
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2017
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Article