Multimodal Fluorescence and Bioluminescence Imaging Reveals Transfection Potential of Intratracheally Administered Polyplexes for Breast Cancer Lung Metastases.

Geyer, Antonia; Taschauer, Alexander; Alioglu, Fatih; Anton, Martina; Maier, Julia; Drothler, Elisabeth; Simlinger, Manuela; Yavuz, Sümeyye; Sami, Haider; Ogris, Manfred

Geyer, Antonia; Taschauer, Alexander; Alioglu, Fatih; Anton, Martina; Maier, Julia; Drothler, Elisabeth; Simlinger, Manuela; Yavuz, Sümeyye; Sami, Haider; Ogris, Manfred.

Afiliação

Geyer A; 1 Laboratory of MacroMolecular Cancer Therapeutics (MMCT), Center of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Vienna , Vienna, Austria .
Taschauer A; 1 Laboratory of MacroMolecular Cancer Therapeutics (MMCT), Center of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Vienna , Vienna, Austria .
Alioglu F; 1 Laboratory of MacroMolecular Cancer Therapeutics (MMCT), Center of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Vienna , Vienna, Austria .
Anton M; 2 Institutes of Molecular Immunology and Experimental Oncology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany .
Maier J; 1 Laboratory of MacroMolecular Cancer Therapeutics (MMCT), Center of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Vienna , Vienna, Austria .
Drothler E; 1 Laboratory of MacroMolecular Cancer Therapeutics (MMCT), Center of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Vienna , Vienna, Austria .
Simlinger M; 1 Laboratory of MacroMolecular Cancer Therapeutics (MMCT), Center of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Vienna , Vienna, Austria .
Yavuz S; 1 Laboratory of MacroMolecular Cancer Therapeutics (MMCT), Center of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Vienna , Vienna, Austria .
Sami H; 1 Laboratory of MacroMolecular Cancer Therapeutics (MMCT), Center of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Vienna , Vienna, Austria .
Ogris M; 1 Laboratory of MacroMolecular Cancer Therapeutics (MMCT), Center of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Vienna , Vienna, Austria .

Hum Gene Ther ; 28(12): 1202-1213, 2017 12.

Article em En | MEDLINE | ID: mdl-28874076

Assuntos

Medições Luminescentes/métodos; Proteínas Luminescentes; Neoplasias Pulmonares; Neoplasias Mamárias Experimentais; Imagem Óptica/métodos; Transfecção/métodos; Células A549; Animais; Feminino; Humanos; Proteínas Luminescentes/biossíntese; Proteínas Luminescentes/genética; Neoplasias Pulmonares/diagnóstico por imagem; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/secundário; Neoplasias Mamárias Experimentais/diagnóstico por imagem; Neoplasias Mamárias Experimentais/genética; Neoplasias Mamárias Experimentais/metabolismo; Neoplasias Mamárias Experimentais/patologia; Camundongos; Camundongos Endogâmicos BALB C; Metástase Neoplásica

Palavras-chave

bioluminescence imaging; breast cancer; intratracheal lung delivery; linear polyethylenimine; near infrared imaging; plasmid DNA

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transfecção / Imagem Óptica / Medições Luminescentes / Proteínas Luminescentes / Neoplasias Pulmonares / Neoplasias Mamárias Experimentais Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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