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The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Nav1.7.
Wright, Zoë V F; McCarthy, Stephen; Dickman, Rachael; Reyes, Francis E; Sanchez-Martinez, Silvia; Cryar, Adam; Kilford, Ian; Hall, Adrian; Takle, Andrew K; Topf, Maya; Gonen, Tamir; Thalassinos, Konstantinos; Tabor, Alethea B.
Afiliação
  • Wright ZVF; Department of Chemistry, University College London , 20 Gordon Street, London WC1H 0AJ, United Kingdom.
  • McCarthy S; Department of Chemistry, University College London , 20 Gordon Street, London WC1H 0AJ, United Kingdom.
  • Dickman R; Department of Chemistry, University College London , 20 Gordon Street, London WC1H 0AJ, United Kingdom.
  • Reyes FE; Janelia Research Campus, Howard Hughes Medical Institute , Ashburn, Virginia 20147, United States.
  • Sanchez-Martinez S; Janelia Research Campus, Howard Hughes Medical Institute , Ashburn, Virginia 20147, United States.
  • Cryar A; Institute of Structural and Molecular Biology, Division of Biosciences, University College London , Gower Street, London WC1E 6BT, United Kingdom.
  • Kilford I; Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, University of London , London WC1E 7HX, United Kingdom.
  • Hall A; European Knowledge Centre, Eisai Limited , Mosquito Way, Hatfield, Hertfordshire AL10 9SN, United Kingdom.
  • Takle AK; European Knowledge Centre, Eisai Limited , Mosquito Way, Hatfield, Hertfordshire AL10 9SN, United Kingdom.
  • Topf M; European Knowledge Centre, Eisai Limited , Mosquito Way, Hatfield, Hertfordshire AL10 9SN, United Kingdom.
  • Gonen T; Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, University of London , London WC1E 7HX, United Kingdom.
  • Thalassinos K; Janelia Research Campus, Howard Hughes Medical Institute , Ashburn, Virginia 20147, United States.
  • Tabor AB; Institute of Structural and Molecular Biology, Division of Biosciences, University College London , Gower Street, London WC1E 6BT, United Kingdom.
J Am Chem Soc ; 139(37): 13063-13075, 2017 09 20.
Article em En | MEDLINE | ID: mdl-28880078
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Venenos de Aranha / Aranhas / Dissulfetos / Canal de Sódio Disparado por Voltagem NAV1.7 / Bloqueadores do Canal de Sódio Disparado por Voltagem Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Venenos de Aranha / Aranhas / Dissulfetos / Canal de Sódio Disparado por Voltagem NAV1.7 / Bloqueadores do Canal de Sódio Disparado por Voltagem Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article