Generation of a novel live rabies vaccine strain with a high level of safety by introducing attenuating mutations in the nucleoprotein and glycoprotein.

Nakagawa, Keisuke; Nakagawa, Kento; Omatsu, Tsutomu; Katayama, Yukie; Oba, Mami; Mitake, Hiromichi; Okada, Kazuma; Yamaoka, Satoko; Takashima, Yasuhiro; Masatani, Tatsunori; Okadera, Kota; Ito, Naoto; Mizutani, Tetsuya; Sugiyama, Makoto

Nakagawa, Keisuke; Nakagawa, Kento; Omatsu, Tsutomu; Katayama, Yukie; Oba, Mami; Mitake, Hiromichi; Okada, Kazuma; Yamaoka, Satoko; Takashima, Yasuhiro; Masatani, Tatsunori; Okadera, Kota; Ito, Naoto; Mizutani, Tetsuya; Sugiyama, Makoto.

Afiliação

Nakagawa K; Laboratory of Zoonotic Diseases, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan; The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan.
Nakagawa K; The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan.
Omatsu T; Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Katayama Y; Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Oba M; Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Mitake H; The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan.
Okada K; The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan.
Yamaoka S; The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan.
Takashima Y; The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan; Laboratory of Veterinary Parasitological Diseases, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan; Gifu Center for Highly Advanced Integration of Nanosciences and Life Sciences (G-CHAIN), Gifu Univ
Masatani T; The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan.
Okadera K; The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan.
Ito N; Laboratory of Zoonotic Diseases, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan; The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan; Gifu Center for Highly Advanced Integration of Nanosciences and Life Sciences (G-CHAIN), Gifu University, Gifu, Japa
Mizutani T; Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Sugiyama M; Laboratory of Zoonotic Diseases, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan; The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan.

Vaccine ; 35(42): 5622-5628, 2017 10 09.

Article em En | MEDLINE | ID: mdl-28882441

Assuntos

Glicoproteínas/genética; Mutação/genética; Nucleoproteínas/genética; Vacina Antirrábica/genética; Vírus da Raiva/genética; Raiva/genética; Vacinas Atenuadas/genética; Substituição de Aminoácidos/genética; Animais; Linhagem Celular Tumoral; Chlorocebus aethiops; Genes Virais/genética; Humanos; Camundongos; Vacinação/métodos; Células Vero

Palavras-chave

Attenuated live vaccine; Gene manipulation; Glycoprotein; Nucleoprotein; Rabies

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Raiva / Vírus da Raiva / Vacinas Atenuadas / Vacina Antirrábica / Glicoproteínas / Mutação / Nucleoproteínas Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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