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Allelic forms of the alpha- and beta-chain genes encoding DQw1-positive heterodimers.
Turco, E; Care, A; Compagnone-Post, P; Robinson, C; Cascino, I; Trucco, M.
Afiliação
  • Turco E; Pittsburgh Cancer Institute, PA 15213.
Immunogenetics ; 26(4-5): 282-90, 1987.
Article em En | MEDLINE | ID: mdl-2888727
On chromosome 6, in the HLA region, the DQ subregion is located immediately centromeric to the DR subregion. Even though only three serological specificities to date have been officially recognized (DQw1, DQw2, and DQw3), it seems likely that the phenotypical polymorphism expressed by DQ molecules is much more complex. There are reasons to believe that fixed alpha-beta combinations exist, each of them associated with a different DR allele. DQw1 is a determinant present on DQ molecules that are found associated with DR1-, DR2-, and DRw6-positive haplotypes. By restriction fragment length polymorphism analysis, we recognized three allelic DQ-alpha and three allelic DQ-beta patterns associated with DQw1. In addition, one of these alpha/beta pairs associated with DR1, two with DR2, and a fourth with DRw6. We have obtained evidence using nucleotide sequencing that there are as many allelic forms of DQ-alpha and DQ-beta genes as there are different molecular DQ-alpha and DQ-beta patterns. The DQ-alpha and DQ-beta chains of DQw1-positive molecules each are encoded by at least three distinctly different allelic genes, and particular alpha/beta gene combinations are associated with the same DR alleles as their corresponding molecular alpha/beta pairs.
Assuntos
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Base de dados: MEDLINE Assunto principal: Antígenos HLA-DQ / Antígenos HLA-D / Genes MHC da Classe II / Alelos Limite: Humans Idioma: En Ano de publicação: 1987 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Antígenos HLA-DQ / Antígenos HLA-D / Genes MHC da Classe II / Alelos Limite: Humans Idioma: En Ano de publicação: 1987 Tipo de documento: Article