MiR-26b reverses temozolomide resistance via targeting Wee1 in glioma cells.
Cell Cycle
; 16(20): 1954-1964, 2017 Oct 18.
Article
em En
| MEDLINE
| ID: mdl-28898169
ABSTRACT
Emerging evidence has demonstrated that microRNAs (miRNA) play a critical role in chemotherapy-induced epithelial-mesenchymal transition (EMT) in glioma. However, the underlying mechanism of chemotherapy-triggered EMT has not been fully understood. In the current study, we determined the role of miR-26b in regulation of EMT in stable temozolomide (TMZ)-resistant (TR) glioma cells, which have displayed mesenchymal features. Our results illustrated that miR-26b was significantly downregulated in TR cells. Moreover, ectopic expression of miR-26b by its mimics reversed the phenotype of EMT in TR cells. Furthermore, we found that miR-26b governed TR-mediate EMT partly due to governing its target Wee1. Notably, overexpression of miR-26b sensitized TR cells to TMZ. These findings suggest that upregulation of miR-26b or targeting Wee1 could serve as novel approaches to reverse chemotherapy resistance in glioma.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Tirosina Quinases
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Proteínas Nucleares
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Proteínas de Ciclo Celular
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Resistencia a Medicamentos Antineoplásicos
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Dacarbazina
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MicroRNAs
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Glioma
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article