Overexpression of F-box only protein 31 predicts poor prognosis and deregulates p38&#945;- and JNK-mediated apoptosis in esophageal squamous cell carcinoma.

Liu, Jia; Lv, Liang; Gong, Jian; Tan, Yuyong; Zhu, Yun; Dai, Yinghuan; Pan, Xin; Huen, Michael S Y; Li, Bin; Tsao, Sai Wah; Huo, Jirong; Cheung, Annie L M

Overexpression of F-box only protein 31 predicts poor prognosis and deregulates p38α- and JNK-mediated apoptosis in esophageal squamous cell carcinoma.

Liu, Jia; Lv, Liang; Gong, Jian; Tan, Yuyong; Zhu, Yun; Dai, Yinghuan; Pan, Xin; Huen, Michael S Y; Li, Bin; Tsao, Sai Wah; Huo, Jirong; Cheung, Annie L M.

Afiliação

Liu J; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, People's Republic of China.
Lv L; Center of Medical Research, The Second Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
Gong J; Department of Gastroenterology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
Tan Y; Department of Gastroenterology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
Zhu Y; Department of Gastroenterology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
Dai Y; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, People's Republic of China.
Pan X; Department of Pathology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
Huen MSY; Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Tai-Ping Road 27, Beijing, 100850, People's Republic of China.
Li B; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, People's Republic of China.
Tsao SW; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, People's Republic of China.
Huo J; The University of Hong Kong-Shenzhen Institute of Research and Innovation (HKU-SIRI), Hong Kong SAR, People's Republic of China.
Cheung ALM; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, People's Republic of China.

Int J Cancer ; 142(1): 145-155, 2018 01 01.

Article em En | MEDLINE | ID: mdl-28905993

Assuntos

Carcinoma de Células Escamosas/patologia; Neoplasias Esofágicas/patologia; Proteínas F-Box/biossíntese; MAP Quinase Quinase 4/metabolismo; Proteína Quinase 14 Ativada por Mitógeno/metabolismo; Proteínas Supressoras de Tumor/biossíntese; Adulto; Idoso; Animais; Apoptose/fisiologia; Carcinogênese/metabolismo; Carcinogênese/patologia; Carcinoma de Células Escamosas/metabolismo; Carcinoma de Células Escamosas/mortalidade; Resistencia a Medicamentos Antineoplásicos/fisiologia; Neoplasias Esofágicas/metabolismo; Neoplasias Esofágicas/mortalidade; Carcinoma de Células Escamosas do Esôfago; Feminino; Humanos; Estimativa de Kaplan-Meier; Masculino; Camundongos; Pessoa de Meia-Idade; Prognóstico; Regulação para Cima; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

FBXO31; JNK; apoptosis; esophageal squamous cell carcinoma; p38α MAPK

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / Carcinoma de Células Escamosas / Proteínas Supressoras de Tumor / Proteínas F-Box / MAP Quinase Quinase 4 / Proteína Quinase 14 Ativada por Mitógeno Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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