Reconfirmation of improved tolerance to a new amino acid-based formula by infants with cow's milk protein allergy.
Asia Pac J Clin Nutr
; 26(6): 1088-1091, 2017.
Article
em En
| MEDLINE
| ID: mdl-28917235
ABSTRACT
BACKGROUND AND OBJECTIVES:
Reasons for intolerance to commercial amino acid-based formulas (cAAF) in infants diagnosed with cow's milk protein allergy (CMA) remain unknown. We assume that minute amounts of proteins, presenting in the glucose polymers derived from corn starch (cGPs), can elicit the intolerance to the cAAFs observed in some infants with CMA. By replacing cGPs with glucose polymers derived from rice starch (rGPs), a new amino acid-based (nAAF) formula has been shown to be better tolerated than an existing cAAF. This study was carried out to corroborate the superiority of nAAF over a different commercially available cAAF. METHODS AND STUDYDESIGN:
Infants with CMA aged less than 4 months underwent a double-blind, placebo-controlled food challenge. They consumed each of the 2 test formulas for 14 days before switching to the other one. Following the 28-day challenge period, infants consumed the tolerated formula for 4 weeks as an at-home open challenge.RESULTS:
Out of 36 infants who completed the study, 18 were intolerant to the cAAF, seven of whom (38.8%) were also intolerant to the nAAF. Eleven of the 18 infants who were intolerant to the cAAF tolerated the nAAF (p<0.01).CONCLUSIONS:
This study reconfirms that substitution of rGPS for cGPs in the amino acid-based formula improves tolerance of young infants with CMA.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Alimentos Formulados
/
Hipersensibilidade a Leite
/
Fórmulas Infantis
/
Aminoácidos
/
Proteínas do Leite
Tipo de estudo:
Clinical_trials
Limite:
Animals
/
Humans
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Infant
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Newborn
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article