A Redox Modulatory Mn3 O4 Nanozyme with Multi-Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model.
Angew Chem Int Ed Engl
; 56(45): 14267-14271, 2017 11 06.
Article
em En
| MEDLINE
| ID: mdl-28922532
ABSTRACT
Nanomaterials with enzyme-like activities (nanozymes) attracts significant interest due to their therapeutic potential for the treatment of various diseases. Herein, we report that a Mn3 O4 nanozyme functionally mimics three major antioxidant enzymes, that is, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the multienzyme activity is size as well as morphology-dependent. The redox modulatory effect of Mn3 O4 plays a crucial role in protecting the cells from MPP+ induced cytotoxicity in a Parkinson disease (PD)-like cellular model, indicating that manganese-based nanomaterials having multi-enzyme activity can robustly rescue the cells from oxidative damage and thereby possess therapeutic potential to prevent ROS-mediated neurological disorders.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Óxidos
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Doença de Parkinson
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Superóxido Dismutase
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Catalase
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Compostos de Manganês
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Citoproteção
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Nanoestruturas
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Glutationa Peroxidase
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article