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4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing.
Malek-Adamian, Elise; Guenther, Dale C; Matsuda, Shigeo; Martínez-Montero, Saúl; Zlatev, Ivan; Harp, Joel; Burai Patrascu, Mihai; Foster, Donald J; Fakhoury, Johans; Perkins, Lydia; Moitessier, Nicolas; Manoharan, Rajar M; Taneja, Nate; Bisbe, Anna; Charisse, Klaus; Maier, Martin; Rajeev, Kallanthottathil G; Egli, Martin; Manoharan, Muthiah; Damha, Masad J.
Afiliação
  • Malek-Adamian E; Department of Chemistry, McGill University , 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
  • Guenther DC; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Matsuda S; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Martínez-Montero S; Department of Chemistry, McGill University , 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
  • Zlatev I; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Harp J; Department of Biochemistry, School of Medicine, Vanderbilt University , Nashville, Tennessee 37232, United States.
  • Burai Patrascu M; Department of Chemistry, McGill University , 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
  • Foster DJ; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Fakhoury J; Department of Chemistry, McGill University , 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
  • Perkins L; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Moitessier N; Department of Chemistry, McGill University , 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
  • Manoharan RM; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Taneja N; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Bisbe A; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Charisse K; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Maier M; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Rajeev KG; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Egli M; Department of Biochemistry, School of Medicine, Vanderbilt University , Nashville, Tennessee 37232, United States.
  • Manoharan M; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Damha MJ; Department of Chemistry, McGill University , 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
J Am Chem Soc ; 139(41): 14542-14555, 2017 10 18.
Article em En | MEDLINE | ID: mdl-28937776
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ribonucleotídeos / Inativação Gênica / Estabilidade de RNA / RNA Interferente Pequeno / Interferência de RNA Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ribonucleotídeos / Inativação Gênica / Estabilidade de RNA / RNA Interferente Pequeno / Interferência de RNA Idioma: En Ano de publicação: 2017 Tipo de documento: Article