High glucose derived endothelial microparticles increase active caspase-3 and reduce microRNA-Let-7a expression in endothelial cells.

Bammert, Tyler D; Hijmans, Jamie G; Reiakvam, Whitney R; Levy, Ma'ayan V; Brewster, Lillian M; Goldthwaite, Zoe A; Greiner, Jared J; Stockelman, Kelly A; DeSouza, Christopher A

Bammert, Tyler D; Hijmans, Jamie G; Reiakvam, Whitney R; Levy, Ma'ayan V; Brewster, Lillian M; Goldthwaite, Zoe A; Greiner, Jared J; Stockelman, Kelly A; DeSouza, Christopher A.

Afiliação

Bammert TD; Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.
Hijmans JG; Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.
Reiakvam WR; Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.
Levy MV; Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.
Brewster LM; Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.
Goldthwaite ZA; Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.
Greiner JJ; Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.
Stockelman KA; Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.
DeSouza CA; Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA. Electronic address: desouzac@colorado.edu.

Biochem Biophys Res Commun ; 493(2): 1026-1029, 2017 11 18.

Article em En | MEDLINE | ID: mdl-28942148

Assuntos

Caspase 3/metabolismo; Micropartículas Derivadas de Células/metabolismo; Células Endoteliais/metabolismo; Glucose/metabolismo; Hiperglicemia/metabolismo; MicroRNAs/genética; Apoptose; Micropartículas Derivadas de Células/genética; Regulação para Baixo; Células Endoteliais/citologia; Ativação Enzimática; Células Endoteliais da Veia Umbilical Humana; Humanos; Hiperglicemia/genética; MicroRNAs/metabolismo

Palavras-chave

Apoptosis; Caspase-3; Endothelial cells; Glucose; MicroRNA; miR-Let-7a

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs / Células Endoteliais / Caspase 3 / Micropartículas Derivadas de Células / Glucose / Hiperglicemia Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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