Acetone promoted 1,4-migration of an alkoxycarbonyl group on a syn-1,2-diamine.
Tetrahedron Lett
; 58(7): 597-601, 2017 02 15.
Article
em En
| MEDLINE
| ID: mdl-28943668
ABSTRACT
A 2-protected cis-amino mitosene undergoes an irreversible acetone promoted isomerization and converts to the 1-isomer. Kinetic studies and DFT calculations of the reaction are reported. An organocatalytic mechanism is proposed, involving a covalent intermediate formed by reaction of the mitosene and acetone.
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MEDLINE
Idioma:
En
Ano de publicação:
2017
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Article