Mechanisms of Graft Rejection and Immune Regulation after Lung Transplant.
Ann Am Thorac Soc
; 14(Supplement_3): S216-S219, 2017 Sep.
Article
em En
| MEDLINE
| ID: mdl-28945475
Outcomes after lung transplant lag behind those of other solid-organ transplants. A better understanding of the pathways that contribute to rejection and tolerance after lung transplant will be required to develop new therapeutic strategies that take into account the unique immunological features of lungs. Mechanistic immunological investigations in an orthotopic transplant model in the mouse have shed new light on immune responses after lung transplant. Here, we highlight that interactions between immune cells within pulmonary grafts shape their fate. These observations set lungs apart from other organs and help provide the conceptual framework for the development of lung-specific immunosuppression.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transplante de Pulmão
/
Rejeição de Enxerto
/
Pulmão
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article